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Hematology and Oncology

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Shared decision-making is being emphasized in new American College of Obstetricians and Gynecologists mammography screening guidelines for women at average risk of breast cancer.

ACOG: Shared Decision-Making Key to Breast Cancer Screening

Critically important for patient's value, preferences be factored into process, ACOG leader says
More than half of patients with advanced cancer who undergo tumor genomic profiling are interested in learning their secondary germline findings

Many With Advanced Cancer Want Secondary Germline Findings Info

Attitudes toward learning influenced by patients' personal disease experience, health status
The presence of clonal hematopoiesis of indeterminate potential is associated with coronary heart disease

Clonal Hematopoiesis Linked to Coronary Heart Disease

CHIP linked to coronary heart disease, myocardial infarction in humans; atherosclerosis in mice
From 1991 to 2014 there was minimal change in health spending by state

1991-2014 Saw Minimal Change in Health Spending Per State

Recession and recovery, implementation of health reform impacted health care coverage
Many men in the control arm of a screening trial undergo prostate-specific antigen testing during 15 years of follow-up

PSA Testing Frequency High in Control Arm of Screening Trial

Over 15 years of follow-up, considerable proportion of men undergo prostate-specific antigen testing
A community-based interventionist-guided weight-loss program is efficacious for early-stage African-American breast cancer survivors

Weight-Loss Program Aids Black Breast Cancer Survivors

Community-based, interventionist-guided weight loss program efficacious for early-stage survivors
For Caucasian patients with chronic hepatitis B

HCC Drops Beyond Five Years of Entecavir/Tenofovir Tx for Hep B

Older age, lower platelets at baseline and year five, liver stiffness ≥12 kPa linked to HCC development
For development of oncology drugs in Japan

Strategies Compared for Cancer Medication Submission Lags

Shorter submission lag for global trial, early-initiation bridging strategy vs late-initiation strategy
Breast cancer risk peaks around the 40s for BRCA1 mutation carriers and around the 50s for BRCA2 carriers

Family Hx, Mutation Position Key Variables in BRCA1/2 Cancer Risk

Study findings provide cancer risk patterns based on BRCA status using prospective data
For patients with previously untreated stage IV or recurrent non-small-cell lung cancer

Nivolumab Doesn’t Up PFS in Stage IV or Recurrent NSCLC

Findings in patients with previously untreated disease with PD-L1 expression level of ≥5 percent