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Chronic kidney disease has a major effect on global health

Chronic Kidney Disease Poses Major Global Health Burden

Burden measured both by direct morbidity, mortality and as a risk factor for cardiovascular disease
Patients with treatment-limiting Physician Orders for Life-Sustaining Treatment are less likely to be admitted to the intensive care unit but may not always receive treatment that is consistent with their wishes

Study Suggests Overtreatment in End-of-Life Care Despite POLST

Rates of ICU admission lower in patients with treatment-limiting orders; 38 percent received discordant care
Ischemic stroke is independently associated with an increased risk for incident poststroke major adverse cardiovascular events in both men and women

Risk of Major Heart Complications Up Shortly Following Stroke

Findings following first-ever ischemic stroke in both men and women, with risk highest within 30 days
Resting heart rate differs greatly between people

Person-to-Person Resting Heart Rates Found to Be Highly Variable

High variability measured between people; individual rates change seasonally
Overweight/obese postmenopausal women have ethnic differences in sitting behavior and in the deleterious association between sitting behavior and cardiometabolic risk

Ethnic Differences in Sitting Behaviors ID’d in Older Women

Longer sitting time, sitting bout duration deleteriously associated with cardiometabolic risk
The antihypertensive medication amlodipine is associated with a lower risk for gout compared with other antihypertensive agents

Amlodipine Better BP Drug for Lower Long-Term Risk for Gout

Compared with chlorthalidone and lisinopril, amlodipine associated with lower risk for gout
Sodium-glucose cotransporter 2 inhibitors protect against cardiovascular disease in patients with type 2 diabetes

Sodium-Glucose Cotransporter 2 Inhibitors Protect the Heart

Findings show benefit for cardiovascular disease in patients with type 2 diabetes regardless of kidney function
Use of low-dose methotrexate is associated with increased risks for adverse events

Risk for Adverse Events Up With Low-Dose Methotrexate

Risks increased for skin cancer and GI, pulmonary, infectious, hematologic adverse events
Thoracic radiation therapy is associated with increased fatigue and dyspnea as well as decreased physical activity

Thoracic Radiation May Increase Fatigue, Dyspnea in Short Term

In patients with lung cancer or lymphoma, increase in heart dose tied to decrease in physical activity
Short-term exposure to fine particulate matter is associated with an increased risk for out-of-hospital cardiac arrest

Exposure to PM2.5 Tied to Out-of-Hospital Cardiac Arrest

Increase in PM2.5 linked to increase in all-cause OHCA on same day, at lags of up to three days