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In outpatient settings

Only Half of Ear, Nose, Throat Infections Receive Recommended Antibiotics

First-line antibiotics prescribed at 50 percent of outpatient visits for pharyngitis, sinusitis, otitis media
The risk for aortic and mitral regurgitation is increased with current and recent fluoroquinolone use

Aortic, Mitral Regurgitation Risk Up With Fluoroquinolone Use

Risk significantly increased for current use and recent use, but not past use within 61 to 365 days
When empirical antimicrobial therapy is initiated in patients with severe manifestations of sepsis

Initiating Empirical Tx for Sepsis Reduces Blood Culture Sensitivity

12 percent difference seen in proportion of positive blood cultures before and after antimicrobial therapy
Hospital-level high-risk antibiotic use is associated with the risk for hospital-associated Clostridioides difficile infection

High-Risk Antibiotic Use Linked to Hospital-Associated C. Difficile

High-risk antibiotic use independently predicts hospital-related Clostridioides difficile infection
Currently

New Anti-CRE Antibiotics Used for 35 Percent of Infections

Ceftazidime-avibactam, meropenem-vaborbactam, plazomicin exceeded IV polymyxins as of Dec. 2018
Postprescription audit and review is a feasible and effective strategy for antimicrobial stewardship in community hospitals

PostRx Antimicrobial Stewardship Feasible in Community Hospitals

Postprescription audit and review effective in settings with limited resources, expertise
Antibiotic prescriptions are associated with a higher risk for rheumatoid arthritis

Antibiotic Use Tied to Higher Risk for Rheumatoid Arthritis

Findings show a dose- or frequency-dependent association; all antibiotic classes linked to higher odds for RA
Oral antibiotic use is associated with an increased risk for colon cancer and a reduced risk for rectal cancer

Oral Antibiotic Use Linked to Risk for Colorectal Cancer

Risk for colon cancer increased, risk for rectal cancer reduced in association with oral antibiotic use
More than 85 percent of patients with urinary tract infection receive antibiotics the same day and more than half are treated with trimethoprim

Most U.K. Patients With UTI Receive Antibiotics on Same Day

Represcription rate at 28 days only 4.1 percent from 2011 to 2015; slight increase seen for men over time
Overuse of broad-spectrum antibiotics is associated with increased mortality and other poor outcomes in adults admitted for community-onset pneumonia

Poor Pneumonia Outcomes Tied to Overuse of Broad-Spectrum Antibiotics

Poor outcomes include higher mortality, longer hospital stay, and greater risk for C. difficile infection