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The U.S. Food and Drug Administration is warning patients with cancers of the blood or lymph nodes who undergo a donor stem cell transplant not to take azithromycin

FDA Warns Against Long-Term Azithromycin Use for Some

Warning for blood cancer patients who have undergone donor stem cell transplant
Individuals with bicuspid aortic valve and mitral valve prolapse have a higher risk of developing infective endocarditis than the general population

Infective Endocarditis More Common with Valve Issues

Antibiotic prophylaxis should be reconsidered with bicuspid aortic valve, mitral valve prolapse
There are significant variations in practice patterns and resource utilization in patients treated by teaching staff for acute exacerbations of chronic obstructive pulmonary disease

Variations in Practice Patterns Seen in Patients Treated for COPD

Differences in use of steroids, antibiotics noted between teaching and non-teaching hospital staff
There is considerable variability in the proportion of visits at which antibiotics are prescribed among traditional medical and retail clinic settings

Inappropriate Prescribing of Abx High in Urgent Care Centers

Patterns of antibiotic prescribing vary substantially by care setting
The U.S. Food and Drug Administration has strengthened current warnings in the prescribing information about fluoroquinolone antibiotics causing significant decreases in blood glucose as well as mental health side effects.

FDA Requires Safety Label Changes for Fluoroquinolones

Changes will describe hypoglycemic coma and clarify and identify mental health side effects
Between 1999 and 2012

Resistant A. Baumannii Rose in Children From 1999 to 2012

Increase seen carbapenem- and cephalosporin-resistant strains, with peak in 2008
Most premature infants receive empirical antibiotic therapy

Most Premature Infants Receive Early Antibiotics

Variation across centers in early antibiotic exposures, prolonged antibiotic administration
For patients with suspected lower respiratory tract infection

Procalcitonin Assay Doesn’t Cut Antibiotic Use in Lower RTI

Provision of assay doesn't result in less antibiotic use for suspected lower respiratory tract infection
Recent use of oral antibiotics is associated with increased odds of nephrolithiasis

Recent Oral Antibiotics Use Tied to Higher Risk of Nephrolithiasis

Findings strongest among those with exposure at a young age and those with recent exposure
Five-day nitrofurantoin is associated with increased likelihood of clinical and microbiological resolution compared with single-dose fosfomycin among women with lower urinary tract infection

Five-Day Nitrofurantoin Beats Single-Dose Fosfomycin for UTI

Increased likelihood of clinical and microbiological resolution for uncomplicated UTI in women