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Progress has been made in slowing antibiotic resistance-associated deaths

Some Progress Made in Slowing Antibiotic Resistance-Linked Deaths

Deaths decreased 18 percent since 2013 report, but more than 2.8 million infections occur each year
Many older adults do not follow instructions related to antibiotic use

Poll: Many Seniors Do Not Follow Instructions Related to Antibiotics

65 percent of those with leftover medication report keeping it, mainly in case of another infection
Postoperative antibiotic prescriptions are associated with reduced rates of infections after facial plastic surgery

Postop Antibiotics Cut Infections After Facial Plastic Surgery

However, longer duration of antibiotics not tied to further decreases in infections
In outpatient settings

Only Half of Ear, Nose, Throat Infections Receive Recommended Antibiotics

First-line antibiotics prescribed at 50 percent of outpatient visits for pharyngitis, sinusitis, otitis media
The risk for aortic and mitral regurgitation is increased with current and recent fluoroquinolone use

Aortic, Mitral Regurgitation Risk Up With Fluoroquinolone Use

Risk significantly increased for current use and recent use, but not past use within 61 to 365 days
When empirical antimicrobial therapy is initiated in patients with severe manifestations of sepsis

Initiating Empirical Tx for Sepsis Reduces Blood Culture Sensitivity

12 percent difference seen in proportion of positive blood cultures before and after antimicrobial therapy
Hospital-level high-risk antibiotic use is associated with the risk for hospital-associated Clostridioides difficile infection

High-Risk Antibiotic Use Linked to Hospital-Associated C. Difficile

High-risk antibiotic use independently predicts hospital-related Clostridioides difficile infection
Currently

New Anti-CRE Antibiotics Used for 35 Percent of Infections

Ceftazidime-avibactam, meropenem-vaborbactam, plazomicin exceeded IV polymyxins as of Dec. 2018
Postprescription audit and review is a feasible and effective strategy for antimicrobial stewardship in community hospitals

PostRx Antimicrobial Stewardship Feasible in Community Hospitals

Postprescription audit and review effective in settings with limited resources, expertise
Antibiotic prescriptions are associated with a higher risk for rheumatoid arthritis

Antibiotic Use Tied to Higher Risk for Rheumatoid Arthritis

Findings show a dose- or frequency-dependent association; all antibiotic classes linked to higher odds for RA