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Although there has been progress in the development of new antibacterial drugs

Progress Made in Developing New Antibacterial Agents

But most recently approved agents have been modifications of existing chemical classes of antibiotics
Omadacycline is noninferior to moxifloxacin for community-acquired bacterial pneumonia and noninferior to linezolid for acute bacterial skin infections

Omadacycline Noninferior to Moxifloxacin for Pneumonia

Second study shows noninferiority to linezolid for acute bacterial skin and skin-structure infections
For patients being treated for bone or joint infection

Oral Antibiotics Noninferior to IV for Bone, Joint Infection

Noninferiority in intention-to-treat analysis; supported by complete-case, per-protocol, sensitivity analysis
Less than half of all outpatient antibiotic prescription fills by privately insured nonelderly adults and children in the United States are appropriate or potentially appropriate

Inappropriate Antibiotic Rx Common in Privately Insured

Only 12.8 and 35.5 percent of fills were appropriate, potentially appropriate in outpatients
Most children younger than 2 years with bronchiolitis seen in U.S. emergency departments and prescribed antibiotics have no documented bacterial coinfection

Antibiotics Often Inappropriately Prescribed for Bronchiolitis in ED

In almost 70 percent of bronchiolitis cases, antibiotics prescribed with no concomitant infection
A new review

Review Shares Best Practices for Evaluating Penicillin Allergy

Verifying reported allergies necessary to improve outcomes, prevent antibiotic resistance
Dermatologists' use of antibiotics to treat inflammatory skin conditions like acne and rosacea is decreasing

Dermatologists’ Rx for Antibiotics Dropped From 2008 to 2016

However, rising use of antibiotics after dermatologic surgical visits is concerning
Most emergency visits by children occur at nonpediatric emergency departments

Antibiotics Prescribed for Children More Often at Nonpediatric EDs

Frequency of guideline-concordant prescribing for respiratory conditions lower at nonpediatric EDs
Patients taking fluoroquinolones may be at higher risk for ruptures or tears in the aorta

FDA: Fluoroquinolones Tied to Heart Vessel Ruptures, Tears

Patients at risk include those with hypertension or certain genetic disorders and the elderly
Antibiotic use in children <24 months of age is associated with a slightly higher body weight at 5 years of age

Early Antibiotic Use May Be Tied to Higher Childhood Body Weight

Antibiotics before age 2 associated with very small increase in body weight at 5 years of age