Tag: Genetics
Oncogenic Variants Identified in ~10 Percent With Appendix Cancer
Mutations identified in MUTYH, in the MLH1 gene, and in other cancer predisposition genes
Education Interacts With Genetic Variants to Increase Myopia Risk
Genotype by education interaction identified for five genetic variants, with increased effect for university-level education
Stable Neurodevelopment Seen for Most Children With Familial High Risk for Schizophrenia
12.8 percent of children with familial high risk for schizophrenia, bipolar disorder transition to different neurocognitive subgroup
AI Algorithm May ID Dysfunctional Immune Profiles in Acute Infection
Machine learning framework used to deploy quantitative sepsis response signature score, which was estimated using seven- or 12-gene signature
Causal Link Identified Between Bipolar Disorder, IBD
Genetically predicted BD significantly positively associated with risk for inflammatory bowel disease
New Platform Matches Patients to Precision Oncology Trials
Clinical trial consents happened 55 days sooner for patients using MatchMiner compared with those using non-MatchMiner channels
Genetic Predisposition to Smoking Causally Linked to Stroke Outcomes
Link remained significant in multivariable Mendelian randomization analyses adjusting for genetically predicted alcohol consumption
Polygenic Risk Score May Predict Sudden Death in Some CAD Patients
High GPSCAD may predict sudden and/or arrhythmic death in patients with coronary artery disease without severe systolic dysfunction
ABO Variants Linked to Risk for Early-Onset Ischemic Stroke
Variants tagging blood groups O1, A1 more strongly linked to early- versus late-onset stroke; genetic risk for VTE also linked to EOS
Cognition Studied in Children at Familial High Risk for Schizophrenia
Neurocognitive impairments noted in seven of 24 measures for children at familial high risk for schizophrenia versus population-based controls
