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Tag: Genetics

Causal Link ID’d for Plasma Caffeine Concentration With Adiposity

Higher genetically predicted plasma caffeine concentrations linked to lower risk for type 2 diabetes, with 43 percent of effect mediated by BMI

Older Women Still at Risk for Cancer With BRCA1/2 Mutations

Risk reduction surgeries before age 50 years substantially cut later cancer risk for those with genetic risk

Nine Novel Prostate Cancer Variants Identified in Men With African Ancestry

Multiancestry polygenic risk score can stratify prostate cancer risk and differentiate risk for aggressive disease

Genetic Susceptibility to Ovarian Cancer Does Not Modify Protective Effect of Aspirin

Study shows that polygenic score does not modify the 13 percent reduction in ovarian cancer risk seen with aspirin

Genetic Risk Scores Tied to Psychiatric Diagnostic Trajectories

Findings seen for major depression, bipolar disorder, schizophrenia

Certain Genetic Variant in Alzheimer Disease Linked to African Ancestry

Increased risk for Alzheimer disease and younger age of onset seen with APOE ε3 R145C missense variation

Avoidant Restrictive Food Intake Disorder Driven by Genetics

Nonshared environmental factors explain 21 percent of the condition in twin study

Study Looks at Clonal Hematopoiesis in Pediatric Cancer Survivors

Clonal hematopoiesis occurs more often in pediatric cancer survivors; is associated with exposures to alkylating agents, radiation, bleomycin

Genetic, Environmental Prenatal Risk Factors Play Role in Early Atopic Dermatitis

Nonmodifiable risk factors include gestational diabetes, maternal history of allergy, prenatal history of eczema

Risk for Contralateral Breast Cancer Higher for Certain Pathogenic Variant Carriers

Women with germline PVs in BRCA1, BRCA2, CHEK2, and PALB2 have elevated risk for contralateral breast cancer