Home Tags Genetics

Tag: Genetics

For patients with advanced-stage pancreatic ductal adenocarcinoma

Platinum Therapy May Up Survival in Pancreatic Cancer With DNA Repair Defects

PFS longer in pancreatic ductal adenocarcinoma with versus without homologous recombination deficiency
Only 3 percent of patients with autism spectrum disorder report having received all recommended clinical genetic testing

Clinical Genetic Testing for Autism Remains Very Low

Based on self-reported data, gap remains between guideline recommendations and clinical practice
The risk for autism spectrum disorder (ASD) is increased for children with an aunt or uncle with ASD

Risk for Autism Spectrum Disorder Up With Affected Aunt, Uncle

Rates of ASD higher for offspring of mothers or fathers with a sibling diagnosed with ASD
Multiple genes predispose African-American women to breast cancer

Multiple Genes Predispose Black Women to Breast Cancer

High risks for breast cancer associated with mutations in BRCA1, BRCA2, PALB2
Large adult body size contributes to the association between genetically predicted larger body size in childhood and coronary artery disease and type 2 diabetes later in life

Link Found Between Body Size in Childhood, Later Life Disease

Larger genetically predicted body size in childhood link to later CAD, T2DM due to large adult body size
Higher alcohol consumption may be causally associated with an increased risk for stroke and peripheral artery disease

High Alcohol Consumption May Be Causally Tied to Stroke, PAD

Some evidence of positive link seen for genetically predicted alcohol consumption with CAD, a-fib, AAA
A model that includes data on clinical and genetic factors and circulating biomarkers may improve risk discrimination for pancreatic cancer

Clinical, Genetic, Biomarker Model IDs Risk for Pancreatic Cancer

Area under the ROC curve estimated by cross-validation was 0.62 for multifactor model
Klotho-VS heterozygosity is associated with a reduced risk for Alzheimer disease and β-amyloid burden in cognitively normal individuals aged older than 60 years who carry apolipoprotein e4

KL-VSHET+ Genotype Linked to Reduced Alzheimer Disease Risk

Gene variant may be protective in those aged 60 to 80 years, cognitively normal, who carry APOE4
The novel coronavirus has been circulating in New York City for longer than previously believed and most cases can be traced back to Europe

COVID-19 Came to New York City From Europe, Not Asia

Specific genetic codes in most New York City viral samples indicate they originated in Europe
Genetic testing is not better at predicting coronary heart disease risk compared with conventional risk factors

Genetic Testing Does Not Enhance Heart Disease Risk Prediction

Polygenic risk score associated with heart disease events, not a better predictor than standard risk factors