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Four Genetic Variants ID’d for Risk for Progressive Multifocal Leukoencephalopathy

All four risk variants were predicted to be deleterious and were located in two immune pathways

Shorter Leucocyte Telomere Length Linked to Dementia Risk

Shorter leucocyte telomere length also associated with smaller total brain volume, white matter volume, hippocampus volume

Alzheimer, Parkinson Disease Share Protective Association at HLA Locus

Protective HLA-DRB1*04 subtypes bind strongly to aggregation-prone tau PHF6 sequence when acetylated at K311

Genetic Evidence Supports Causal Effect for Diastolic BP on Benign Prostatic Hyperplasia

Risk effect of diastolic blood pressure on benign prostatic hyperplasia persists after conditioning with waist circumference

Plasma ctDNA Genotyping Can Accelerate Time to Treatment for NSCLC

Median time to treatment was 39 days for ACCELERATE cohort versus 62 days for reference cohort using standard tissue genotyping

Genes Identified in Association With Multiple Sclerosis Severity

Significant association identified with rs10191329 in the DYSF-ZNF638 locus, with risk allele shortening time to needing walking aid

Moderate- to Vigorous-Intensity Physical Activity Cuts Diabetes Risk

Larger absolute risk reduction seen among those with the highest genetic risk

Genetically Adjusted PSA Levels Improve Prediction of Prostate Cancer

Genetically adjusted prostate-specific antigen more predictive of aggressive prostate cancer than unadjusted PSA

ASCO: Germline Testing Underused in Cancer Patients

Rates of testing lower among Asian, Black, and Hispanic patients versus White patients

Genetic Links Seen for HDL Cholesterol, Systolic BP With Alzheimer Disease

Genetically determined high-density lipoprotein cholesterol and systolic blood pressure linked to increased odds of Alzheimer disease