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Genomic recurrence score testing using a 21-gene assay is associated with decreased cancer care costs in real-world practice among certain patients with breast cancer who would otherwise receive standard chemotherapy

Recurrence Score May Cut Costs for High-Risk Breast Cancer Care

Testing with 21-gene assay linked to lower relative, absolute costs among high-risk patients
Only one-quarter of those with breast cancer and one-third with ovarian cancer undergo genetic testing

Genetic Testing Underused in Breast, Ovarian Cancer

Pathogenic variants ID'd in 7.8 percent of patients with breast cancer, 14.5 percent with ovarian cancer
In certain cases

Genetic Research Results May Warrant Updates to Participants

Participants should be recontacted in some cases of new information about variant, newly ID'd variants
For patients with FMS-like tyrosine kinase 3 mutations who have relapsed or refractory acute myeloid leukemia

AACR: Longer Survival With Gilteritinib in FLT3mut+ AML

Longer overall survival, better remission rates seen for patients receiving gilteritinib versus salvage chemo
Recommendations have been developed for the use of genetic testing in psychiatric care

Recommendations Presented on Genetic Testing in Psychiatry

Guidelines emphasize that common genetic variants are not sufficient to cause psychiatric disorders
Higher levels of sex hormones

ENDO: Sex Hormone Levels Tied to Telomere Length in Older Men

Estradiol independently linked to leucocyte telomere length in older men; SHBG inversely associated
Having affected first-degree

Having Affected Relatives Linked to Increased Alzheimer Risk

Increased Alzheimer disease risk seen with having affected first-, second-, or third-degree relatives
The correlation between reproductive events and breast cancer risk varies for BRCA1 and BRCA2 mutation carriers

Parity, Risk for Breast Cancer Studied for BRCA1/2 Carriers

Higher risk seen in uniparous BRCA1 carriers, parous BRCA2 carriers; breastfeeding cuts risk in BRCA1
Genetic testing should be made available to all patients with a history of breast cancer

Genetic Testing Recommended for All Patients With Breast Cancer

All with personal history of breast cancer should be offered testing; updated testing recommended
In men

Endogenous Testosterone Linked to Cardiovascular Disease

Genetically predicted endogenous testosterone may have role in thromboembolism, heart failure, MI