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There seems to be a causal association between circulating insulin-like growth factor-1 concentrations and breast cancer

Causal Link Suggested for IGF-1 Concentrations, Breast Cancer

In Mendelian randomization analyses, increase in genetically predicted IGF-1 linked to breast cancer
Among women with a history of gestational diabetes mellitus

Genetic Risk Linked to T2DM in Women With History of GDM

Modest link found for genetic risk score with T2DM risk; link seems stronger for those with poorer dietary quality
In a cohort of unselected postmenopausal women with breast cancer

Genetic Mutations ID’d in Breast Cancer After Menopause

3.55 percent of unselected postmenopausal women with breast cancer have pathogenic variants
Expansion of National Comprehensive Cancer Network hereditary cancer testing criteria to include all women diagnosed with breast cancer at ≤65 years would improve the sensitivity of detection of germline pathogenic variants

Genetic Testing Proposed for All Women ≤65 With Breast Cancer

Expanded testing could increase detection of carriers for BRCA1/2, mutations in other predisposition genes
Receipt of molecularly matched therapy is associated with improved outcomes in patients with pancreatic cancer

Molecularly Matched Therapy Promising in Pancreatic Cancer

Overall survival significantly longer for patients with actionable molecular alterations receiving matched tx
A proposed project to map the genes of 1 million people in New York living with or at risk for Alzheimer disease was announced Friday by Gov. Andrew Cuomo.

Alzheimer Disease Gene Mapping Project Proposed in New York State

Governor says initiative will help researchers working to slow the progression of Alzheimer disease
Maximal resection of a contrast-enhanced tumor is associated with improved overall survival in patients with isocitrate dehydrogenase gene 1 or 2 (IDH)-wild-type and IDH-mutant subtype glioblastomas

Maximal Resection of Glioblastomas May Up Survival

Maximal resection of contrast-enhanced tumor linked to increased overall survival across all subgroups
The genetic determinants of testosterone levels differ between the sexes

Genetic Basis for Testosterone Levels Differs According to Sex

Genetically higher testosterone level generally benefits men, harms women in metabolic diseases
Among those who have Helicobacter pylori infection and a family history of gastric cancer in first-degree relatives

H. pylori Eradication Cuts Gastric Cancer Risk in Those With Family History

Gastric cancer risk reduced among those with H. pylori infection plus first-degree relatives with gastric cancer
Obesity does not necessarily induce or contribute to familial psoriasis

Familial Psoriasis May Not Be Tied to Obesity

Patients with familial psoriasis were younger, had a lower BMI at diagnosis versus nonfamilial psoriasis