Tag: Genetics
Four Genetic Variants ID’d for Risk for Progressive Multifocal Leukoencephalopathy
All four risk variants were predicted to be deleterious and were located in two immune pathways
Shorter Leucocyte Telomere Length Linked to Dementia Risk
Shorter leucocyte telomere length also associated with smaller total brain volume, white matter volume, hippocampus volume
Alzheimer, Parkinson Disease Share Protective Association at HLA Locus
Protective HLA-DRB1*04 subtypes bind strongly to aggregation-prone tau PHF6 sequence when acetylated at K311
Genetic Evidence Supports Causal Effect for Diastolic BP on Benign Prostatic Hyperplasia
Risk effect of diastolic blood pressure on benign prostatic hyperplasia persists after conditioning with waist circumference
Plasma ctDNA Genotyping Can Accelerate Time to Treatment for NSCLC
Median time to treatment was 39 days for ACCELERATE cohort versus 62 days for reference cohort using standard tissue genotyping
Genes Identified in Association With Multiple Sclerosis Severity
Significant association identified with rs10191329 in the DYSF-ZNF638 locus, with risk allele shortening time to needing walking aid
Moderate- to Vigorous-Intensity Physical Activity Cuts Diabetes Risk
Larger absolute risk reduction seen among those with the highest genetic risk
Genetically Adjusted PSA Levels Improve Prediction of Prostate Cancer
Genetically adjusted prostate-specific antigen more predictive of aggressive prostate cancer than unadjusted PSA
ASCO: Germline Testing Underused in Cancer Patients
Rates of testing lower among Asian, Black, and Hispanic patients versus White patients
Genetic Links Seen for HDL Cholesterol, Systolic BP With Alzheimer Disease
Genetically determined high-density lipoprotein cholesterol and systolic blood pressure linked to increased odds of Alzheimer disease
