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The multigene expression test Oncotype DX is not cost-effective for women with breast cancer who are at low risk for recurrence

Oncotype DX Not Cost-Effective for Low-Risk Breast Cancer

Incremental cost-effectiveness ratio varies across clinical risk groups, sensitive to patient age
The U.S. Preventive Services Task Force (USPSTF) recommends screening for women at increased risk for carrying a BRCA1/2 mutation as well as genetic counseling and testing as indicated for those screening positive. These recommendations form the basis of a draft recommendation statement published online Feb. 19 by the USPSTF.

USPSTF Says Screen Women With Higher Risk for BRCA Mutations

Those with positive results should be provided with genetic counseling, testing if indicated
An improved type 1 diabetes (T1D) genetic risk score (GRS)

Improved Genetic Risk Score Aids Type 1 Diabetes Classification

Revised risk score also improves newborn screening versus HLA genotyping alone
Objectively assessed physical activity is associated with a protective relationship with major depressive disorder

Objectively Assessed Exercise Protective Against Depression

Objectively assessed, but not self-reported, physical activity protects against major depressive disorder
Among breast cancer patients

Breast Cancer Patients Do Not Overreact to Genetic Testing

No increased cancer worry for multigene panel testing versus BRCA1/2-only test after cancer diagnosis
HFE p.C282Y homozygosity

Hemochromatosis Mutation Linked to Other Morbidity

Higher rates of at least one incident-linked condition seen in men, women with HFE p.C282Y homozygosity
The influence of heritability and environmental factors has been identified for a large number of phenotypes

Study Explores Influence of Genetics, Environment in Disease

Genetic component for 40 percent of phenotypes studied; 25 percent have environmental risk factors
Newborn genomic sequencing can detect the risk for disease onset during childhood and actionable adult-onset disease

Newborn Genomic Sequencing Can Identify Disease Risk

Sequencing detects risk for disorders not anticipated based on infants' known clinical, family history
Three novel loci have been identified for polycystic ovary syndrome

Three Novel Loci Associated With Polycystic Ovary Syndrome ID’d

Genetic links with obesity, T2DM, lipids suggest shared genetic architecture for PCOS, metabolic traits
Genes are responsible for approximately one in 10 cases of chronic kidney disease in adults

Exome Sequencing Provides Genetic Diagnosis for Some With CKD

Genetic diagnosis for 9.3 percent of 3,315 patients with chronic kidney disease from two cohorts