Tag: Genetics

Independent risk factors for rheumatoid arthritis (RA)-associated ILD include MUC5B rs35705950 T risk allele, male sex, older age at RA onset

Patients with rs2814778-CC also have lower last leukocyte count and lower dosing; findings persist after adjustment for race

Heterozygous carriers of HMGCR predicted loss-of-function variants had higher risks for developing cataract, cataract surgery

Magnitudes of gene-specific risks for triple-negative breast cancer similar across racial/ethnic groups

ctDNA-guided approach to determining the need for adjuvant therapy noninferior to standard management for recurrence-free survival

Mendelian randomization phenome-wide association study performed to examine relationship between height and clinical traits

Genomic, proteomic, and metabolomic biomarkers identified from systematic review of relevant studies

For adults aged 20 to 39 years, clinical criteria alone would yield 1.3 cases per 1,000 screened; adding genetic testing would increase the yield to 4.2 cases

Lifestyle intervention effective in reducing age-adjusted occurrence of GDM only among those with the highest genetic risk for type 2 diabetes

Participants with high PRS had increased risk for joint replacement; stronger association seen with hip replacement for women versus men