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Medical science has made tremendous advances in personalized medicine. However

Many Americans Unaware of Promise of Personalized Medicine

41 percent are not at all familiar with personalized medicine; only 5 percent say they are very familiar
Though common breast cancer variants indicate increased breast cancer risk

Rare Variants Associated With Interval Breast Cancers

The presence of these variants is also linked to increased risk for death
The interpretation of genomic epilepsy tests has evolved rapidly in the last five years

Results of Pediatric Genomic Epilepsy Tests Often Reclassified

Over 30 percent of pediatric patients with genetic dx, undiagnosed conditions had results reclassified
A multigene genomic classifier test for thyroid nodules with indeterminate cytology shows high sensitivity and negative predictive value

Genetic Test Helps ID Benign Versus Malignant Thyroid Nodules

ThyroSeq v3 has 94 percent sensitivity, 82 percent specificity for Bethesda III and IV nodules
A polygenic risk score for schizophrenia can predict 12-week posttreatment symptom scores among patients with first-episode psychosis

Polygenic Risk Score Predicts Tx Response in Schizophrenia

PRS significantly predictive of adjusted 12-week symptom scores across four cohorts
A polygenic risk score can identify subsequent breast cancer risk among childhood survivors of cancer

Genetic Risk Score IDs Breast CA Risk in Female Child CA Survivors

Survivors in highest quintile of polygenic risk score have increased relative rate of breast cancer
A lack of understanding of terminology

Barriers to Prostate Cancer Research in Black Men Identified

Mistrust, lack of knowledge, unfavorable attitudes are barriers to genomic testing, study participation
Integration of plasma next-generation sequencing into the routine management of metastatic non-small cell lung cancer results in an increase in the detection of therapeutically targetable mutations

Plasma-Based Genotyping Aids Targeted Tx of Metastatic NSCLC

Most patients who received targeted therapy based on plasma result achieved clinical response
Diet explains little of the variation in serum urate levels in the general population

Diet Less Important Than Genes for High Serum Urate Levels

Certain foods linked to high or low serum urate levels, but dietary scores have limited contribution
Exome sequencing-based screening may identify pathogenic and likely pathogenic BRCA1/2 variants that might otherwise remain undetected

Genomic Screening Can ID Undetected BRCA1/2 Cancer Risk

82 percent of variant carriers identified in exome sequencing had not undergone prior testing