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An inherited form of adult-onset hearing loss is relatively common

Genetic Variant Identified for Adult-Onset Hearing Loss

12 nucleotide in-frame deletion in RIPOR2 identified as highly penetrant cause of hearing loss
Different genetic test interpretations have been identified for genetic variants

Genetic Tests May Differ in Their Interpretation of Certain Variants

11 percent of interpretations were different for TP53 gene; difference can impact management
Patients with COVID-19 and severe disease have associations at locus 3p21.31 and 9q34.2

Genomewide Level Associations Identified for Severe COVID-19

Association signal spanning several genes ID'd at 3p21.31; signal at 9q34.2 coincides with ABO locus
Distinct subtypes of polycystic ovary syndrome with novel genetic associations have been identified

Subtypes, Genetic Links Identified for Polycystic Ovary Syndrome

Alleles in four loci linked to reproductive subtype, in one locus linked to metabolic subtype of PCOS
Metabolic traits associated with adult diabetes risk may be detectable by age 8 years

Adult T2DM Susceptibility May Be Identifiable in Children

Subtle differences in metabolic features of young people seen from 8 to 25 years of age
For patients with Lynch syndrome

Aspirin Tied to Lasting Reduction in CRC Risk in Lynch Syndrome

Reduced risk for colorectal cancer seen in intention-to-treat and per-protocol analyses
Women at risk for hereditary breast and ovarian cancer who undergo genetic testing without receiving pretest and posttest counseling and only receive electronic education are at no increased risk for posttest stress

ASCO: At-Home Ovarian, Breast Cancer Genetic Testing Feasible

Testing without the traditional office visits and counseling poses no additional stress to women
For patients with advanced-stage pancreatic ductal adenocarcinoma

Platinum Therapy May Up Survival in Pancreatic Cancer With DNA Repair Defects

PFS longer in pancreatic ductal adenocarcinoma with versus without homologous recombination deficiency
Only 3 percent of patients with autism spectrum disorder report having received all recommended clinical genetic testing

Clinical Genetic Testing for Autism Remains Very Low

Based on self-reported data, gap remains between guideline recommendations and clinical practice
The risk for autism spectrum disorder (ASD) is increased for children with an aunt or uncle with ASD

Risk for Autism Spectrum Disorder Up With Affected Aunt, Uncle

Rates of ASD higher for offspring of mothers or fathers with a sibling diagnosed with ASD