Tag: Genetics
Many Breast Cancer Survivors With Indications for Genetic Testing Do Not Receive It
Findings not just following diagnosis, but six years after diagnosis
Link Between T2DM, Spinal Degenerative Disorder May Be Method-Dependent
T2DM was an independent risk factor for SDD in logistic regression analysis; no causal relationship seen in MR analyses
Neighborhood Disadvantage Metrics Tied to Stress Genes in Prostate Cancer
Expression of several stress-related genes increased in prostate tumors for men living in disadvantaged neighborhoods
Air Pollution Exposure Tied to New Psoriasis
Increase in psoriasis risk also seen among those with higher genetic vulnerability and increased exposure to air pollutants
Parents’ Weight Status at Age 17 Correlates to Offspring Weight at 17
Maternal, paternal obesity at age 17 years tied to fivefold higher odds of offspring obesity at age 17 years
Rare Predicted Loss-of-Function Variants, Polygenic Risk Score Linked to Risk of A-Fib
Odds ratio of 7.08 for atrial fibrillation for rare pLOF variants combined with high polygenic risk score
SNP rs13194504 AA Genotype Linked to Severity of Tardive Dyskinesia
AA genotype linked to reduced severity, but not occurrence, of TD; no association seen for rs210133 with TD occurrence, severity
Study Quantifies Risk for Gastric, Breast Cancer for Germline CDH1 P/LP Variants
Lifetime cumulative risk for advanced gastric cancer 10.3 and 6.5 percent for male and female carriers, respectively
Cognitive Impairment Delayed With Genetic Variant
Onset of cognitive impairment delayed among those heterozygous for the apolipoprotein E3 Christchurch variant
Females Have Higher Genetic Risk for PTSD
Unique environmental effects, but not a shared environment between siblings, also influences risk
