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Neratinib, Fulvestrant, Trastuzumab Combo Aids Metastatic Breast Cancer

Three-drug combination beneficial for HR-positive HER2-mutant metastatic breast cancer with prior CDK4/6i therapy

Fluvoxamine Does Not Shorten Duration of COVID-19 Symptoms

Findings observed among adults with mild or moderate COVID-19

Two-Week DAA Prophylaxis Prevents Hep C After Kidney Transplant

Two-week DAA optimal for preventing infection in individuals without HCV viremia who received kidney from HCV-viremia-positive donors

Long-Term Exposure to ADHD Meds Linked to Increased Risk for CVD

4 percent increase in risk for CVD seen in association with each one-year increase in ADHD meds across 14 years of follow-up

Disease-Modifying Therapy Use for Sickle Cell Remained Low 2014 to 2021

Inconsistent users of DMT had higher prevalence of vaso-occlusive crises, splenic complications, health care visits

Ubrogepant Beneficial for Treating Migraine During the Prodrome

Absence of moderate or severe headache reported in 46 and 29 percent of prodrome events that had been treated with ubrogepant, placebo

Publication Bias Inflates Apparent Efficacy of Alprazolam XR

One of five trials in the FDA review was positive; all three trials in the published literature were positive

Recommendations Developed for Atopic Dermatitis Therapies

Guidelines include strong recommendations for monoclonal antibodies and JAK inhibitors

Gantenerumab Does Not Slow Clinical Decline in Early Alzheimer Disease

Two trials show lower amyloid plaque burden with gantenerumab versus placebo at 116 weeks

Obinutuzumab Preserves Kidney Function in Lupus Nephritis

Reduction seen in risk for developing composite kidney outcome