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Maternal exposure to fluconazole during pregnancy may increase the risk for spontaneous abortion

Prenatal Fluconazole Exposure Increases Neonatal Risks

Any exposure increases spontaneous abortion risk; cardiac septal defects up for use in early pregnancy
Long-term outcomes are more favorable for early intensive treatment versus first-line moderate-efficacy disease-modifying therapy in multiple sclerosis

Early Intensive Treatment May Improve Long-Term MS Outcomes

Mean five-year change lower in Expanded Disability Status Scale score with early intensive treatment
For first-line therapy of metastatic renal cell carcinoma

Combo Regimens Effective for Tx of Metastatic Renal Cell Cancer

Two large trials show benefits for pembrolizumab-axitinib and avelumab-axitinib versus sunitinib
Despite adequate levels of prescriber

Inappropriate Use of Fentanyl Preps Seen Despite Awareness

Claims data show many prescribed transmucosal immediate-release fentanyl were opioid-nontolerant
Metastasis-free survival is significantly longer among men with nonmetastatic

Darolutamide Slows Spread of Castration-Resistant Prostate Cancer

Significant survival benefit seen, adverse events similar between darolutamide and placebo
For denosumab-treated women with postmenopausal osteoporosis

Rates of Osteonecrosis of the Jaw Low for Denosumab-Treated Women

Invasive oral procedures associated with increased incidence of ONJ, but rate low overall
Physicians treating certain cancers who consistently receive payments from a cancer drug's manufacturer are more likely to prescribe that drug instead of other treatments

Drug Company Payments Over Time May Influence Rx Practices

Payment consistency, high amount, compensation payments tied to cancer drug prescribing practices
An expert panel for the U.S. Food and Drug Administration has endorsed a drug for major depressive disorder that is a close relative to ketamine.

FDA Panel Backs Ketamine-Like Drug for Depression

Esketamine is a nasal spray that targets different pathways in the brain than other antidepressants do
For adults with chronic hepatitis C virus infection

Direct-Acting Antivirals Cut Mortality in Chronic Hepatitis C

Mortality, hepatocellular carcinoma risk reduced after adjustment for potential confounders
The reversal agent

ASA: Reversal Agent Cuts Severe Bleeding With Factor Xa Inhibitors

Bolus plus two-hour infusion of andexanet alfa cuts antifactor Xa activity by 92 percent