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Triple therapy with VX-659 or VX-445 combined with tezacaftor-ivacaftor shows promise for the treatment of adult patients with cystic fibrosis who have mutations in the cystic fibrosis transmembrane conductance regulator

Triple Combo Regimens May Address Cause of Cystic Fibrosis

Promising results for VX-659-, VX-445-tezacaftor-ivacaftor for cystic fibrosis with mutations in CFTR
From 2014 to 2016 there was an increase in the annual number of HIV preexposure prophylaxis (PrEP) users in the United States

2014 to 2016 Saw 470 Percent Increase in HIV PrEP Use in U.S.

~7 percent of those with indications for PrEP were prescribed PrEP, including 2.1 percent of women
A seven-day dose of metronidazole is associated with reduced likelihood of being Trichomonas vaginalis-positive at test of cure compared with single-dose treatment

Seven-Day Metronidazole Better for Trichomoniasis Tx in Women

Women in the seven-day-dose group less likely to be positive at test of cure versus single-dose group
For patients with chronic obstructive pulmonary disease and comorbid posttraumatic stress disorder

Long-Term Benzodiazepines Do Not Up Mortality in COPD, PTSD

No difference in mortality, but risk for suicide elevated with long-term benzodiazepine use
Two subanesthetic dosages of ketamine appear to provide significant symptom relief to patients with treatment-resistant depression

Dose Range of IV Ketamine for Adjunct Tx of Depression Tested

Single IV doses of 0.5 or 1.0 mg/kg better than active placebo at cutting depression symptoms
For patients with chronic sciatica

Gabapentin Beats Pregabalin for Chronic Sciatica

More frequent adverse events seen with pregabalin, especially when taken before gabapentin
Halobetasol propionate 0.01 percent lotion (BRYHALI Lotion) appears safe and effective for the treatment of moderate-to-severe plaque psoriasis

Halobetasol Propionate Lotion Shows Efficacy for Tx of Psoriasis

Findings based on two phase 3 trials of halobetasol propionate lotion versus vehicle
Two bills that allow U.S. pharmacists to disclose drug prices to customers to help them save money are expected to be signed today by President Donald Trump.

Trump to Sign Bills Lifting Drug Price ‘Gag Orders’ on Pharmacists

Bills will let U.S. pharmacists disclose cash versus insurance costs for medications
Selective inhibition of TYK2 with the oral agent BMS-986165 at doses of 3 mg daily and higher results in greater clearing of psoriasis versus placebo over 12 weeks

TYK2 Inhibitor Clears Psoriasis Over 12 Weeks

Findings seen in 12-week, phase 2 trial at oral doses over 3 mg daily
Receiving prescriptions from both the U.S. Department of Veterans Affairs and Medicare Part D is associated with increased risk for overlapping of opioid and benzodiazepine prescriptions

Risk of Opioid-Benzodiazepine Overlap Up for Dual Prescribing

Increased risk for overlap, high-dose overlap for those with dual use of VA and Medicare drug benefits