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Gut microbes may promote cytotoxic T-cell infiltration in tumors

CRC Tumor Cells Exposed to Gut Bacteria Express Chemokines

Antibiotic treatment of orthotopic tumor-bearing mice reduced chemokine expression levels
Outcomes of treatment with third-generation CAR T-cell therapy in CD19-positive B-cell malignancy are associated with patients' immune status

Immune Status Tied to Outcomes in Third-Gen CAR T-Cell Therapy

In leukemia/lymphoma, after treatment CD19-targeting chimeric antigen receptor T-cell therapy
Injection of inactivated modified vaccinia virus Ankara into tumors is effective and generates antitumor immunity

Inactivated Vaccinia Virus Shows Promise Against Advanced Cancer

Combined with immune checkpoint blockade therapy, iMVA generates synergistic antitumor effects
For elderly patients treated with vitamin K antagonists for venous thromboembolism

CYP2C9 Variants Linked to Clinical Events in VTE

Risk of any clinical event, death, non-major bleeding up for seniors treated with vitamin K antagonists
For patients with cirrhosis

CRP, PCT Added to MELD Ups Prediction of Mortality in Cirrhosis

Addition of C-reactive protein, procalcitonin to model for end-stage liver disease score beneficial
Refractory Helicobacter pylori infection can be successfully treated with goshuyuto and rabeprazole

Goshuyuto, Rabeprazole Shown to Treat Refractory H. pylori

3 cases successfully treated after eradication was not achieved with vonoprazan-based triple therapy
Infants who receive general anesthesia for surgery before they're 1 year old may have less white matter in their brains

General Anesthesia in Infants May Affect White Matter Volume

Small study finds reduction in white matter among children operated on as infants
Re-analysis of evidence suggests that screening does reduce prostate cancer mortality

Re-Analysis Shows Screening Reduces Prostate CA Mortality

In re-analysis, screening conferred 7 to 9 percent reduction in risk in ERSPC and PLCO trials

August 2017 Briefing – Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for August 2017. This roundup includes the latest...
There is organ-dependent crosstalk between adipose tissue and carcinomas in various organs

Crosstalk Identified Between Adipose Tissue, Carcinomas

Organ-dependent crosstalk identified via VEGF, IL6, TNFα, and other mechanisms