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Infectious Disease

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Moderna Starts Testing COVID-19 Vaccine in Younger Children

Company also testing its vaccine in 3,000 older children, ages 12 to 17 years

Intratumoral infusion of recombinant nonpathogenic polio-rhinovirus chimera can be delivered safely and is tied to higher survival rates than those of historical controls

Polio-Rhinovirus Promising for Malignant Glioma Patients

Intratumoral infusion appears to be safe, improve survival in those with grade IV malignant glioma
Among veterans with posttraumatic stress disorder

Death From Specific Causes Up for Veterans With PTSD

Significant increases seen in mortality from suicide, accidental injury, viral hepatitis

Many U.S. Nursing Home Residents Have Not Been Vaccinated for Flu, COVID-19, or RSV...

Second study shows that 42.2 and 18.3 percent of individuals aged 18 years and older reported receiving flu, updated COVID-19 shots

Pfizer Asks FDA to Approve Omicron-Specific Booster Shot

Animal studies show that the new mRNA vaccine produces an immune response against both BA.4 and BA.5 subvariants

The cheap and widely available steroid dexamethasone reduced the risk for death among seriously ill COVID-19 patients by up to a third

Steroid May Reduce COVID-19 Death Risk by Up to One-Third

Dexamethasone appears promising for patients with severe illness
Pediatric patients have a prolonged period of viral shedding after infection with severe acute respiratory syndrome coronavirus 2

Prolonged Viral Shedding Seen in Children Positive for SARS-CoV-2

Median duration of viral shedding 19.5 days; median of 18 days found from RT-PCR positivity to seropositivity

Children Less Susceptible to SARS-CoV-2 but More Infectious

Asymptomatic individuals less likely to infect others; symptomatic cases more likely to infect others before symptom onset

For patients with staphylococcal bacteremia

Algorithm-Defined Tx Duration Non-Inferior in Staph Bacteremia

Non-inferior rate of clinical success for algorithm defining treatment duration versus usual care
For children with complicated pneumonia

IV, Oral Antibiotics Compared for Complicated Pneumonia

No difference in post-discharge treatment failure; more complications, adverse drug events for PICC