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Hematology and Oncology

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Breast implants are associated with an increased risk of anaplastic large-cell lymphoma in the breast

Breast Implants Slightly Increase Risk of Breast ALCL

Implants tied to increased risk of anaplastic large-cell lymphoma; overall risk still very small
Although patients with pre-existing autoimmune disease who receive checkpoint inhibitors (CPIs) are at risk for exacerbation of their disease

Immune-Related Adverse Events Up With Checkpoint Inhibitors

Most patients with cancer, autoimmune disease have improvement in events without discontinuing therapy
Few modern

Few Immuno-Oncology Agents Reach ASCO Efficacy Thresholds

Durable survival, response rates rarely recognized as significant by current oncology value frameworks
Hematopoietic stem/progenitor cell-derived chimeric antigen receptor T-cells are capable of long-term engraftment in a model of HIV/AIDS

HSPC-Derived CAR T-Cells Capable of Lasting Engraftment

Chimeric antigen receptor T-cells persisted more than 2 years without measurable toxicity in primate model

December 2017 Briefing – Hematology & Oncology

Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for December 2017. This roundup includes...
A same-day

Same-Day, Low-Dose Bowel Prep Feasible for Colonoscopy

For inpatients at high risk of poor bowel prep, same-day 1-liter polyethylene glycol-based prep effective
Laser monotherapy improves health-related quality of life in female patients with radiation-induced breast telangiectasias

Laser Improves QOL for Breast Telangiectasia Due to Radiation

Significant improvements seen in emotional and functional Skindex-16 HR-QOL domains, overall score
Obstetrician-gynecologists should be aware of who is eligible for cascade testing

ACOG Advocates Cascade Testing for Hereditary Gene Mutations

Ob-gyns should identify eligible patients, offer testing, and assist in decreasing barriers to testing
Pharmaceutical aids are not effective for increasing long-term smoking cessation

Pharmaceutical Aids Not Found to Be Helpful for Smoking Cessation

No evidence that varenicline, bupropion, or nicotine replacement increase probability of abstinence
There are noticeable differences in hospice utilization among patients with malignant glioma

Variation Seen in Hospice Use for Malignant Glioma

Differences by race, sex, age, level of education, urban versus rural residence identified