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Psychiatry

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Females with anorexia nervosa have lower gut microbial diversity

Lower Microbial Diversity in the Gut in Anorexia Nervosa

Alpha diversity lower in anorexia nervosa, obese participants versus other groups; highest for athletes
Adolescents with depression who are poor responders to treatment do not have more densely connected networks

Network Density Not Linked to Response in Teen Depression

No significant association between higher network strength and poorer outcomes
Sublocade

FDA Approves Once-Monthly Injection for Opioid Addiction

Sublocade has been shown to reduce opioid withdrawal symptoms and the desire to use opioids
Women at both extremes of the weight spectrum have low mean serum allopregnanolone

Mean Serum Allopregnanolone Low Across Weight Extremes

Also tied to increased depression and anxiety severity, independent of body mass index
The combination of environmental enrichment and magnesium-L-threonate is more effective than either treatment alone for improving cognition and spatial memory in a mouse model of Alzheimer's disease

Magnesium Boosts Environmental Enrichment in Alzheimer’s

Combination of EE, magnesium-L-threonate more effective than either treatment alone in mouse model
Older adults report feeling confident that they know how to avoid drug interactions despite only 35 percent having spoken to someone about it in the past year

Many Seniors Have Not Discussed Avoiding Drug Interactions

69 percent of patients see multiple doctors, 21 percent use multiple pharmacies, complicating issue
The Value-Based Payment Modifier is not associated with performance differences between practices serving higher-risk and lower-risk patients

Value-Based Payment Modifier Not Tied to Practice Performance

Performance differences between practices narrowed after adjustment for patient characteristics
Clinician denial of some types of tests requested by patients is associated with worse patient satisfaction with the clinician

Clinician Denial of Patient Requests Impacts Satisfaction

Worse satisfaction in association with denial of request for referral, pain meds, other meds, lab tests
For reversal of opioid overdose

Similar Efficacy for Intranasal, Intramuscular Naloxone

Similar efficacy for higher-concentration intranasal naloxone, IM naloxone administered at same dose
Heart rate variability and specific inflammatory biomarkers can differentiate major depressive disorder from depression in bipolar disorder

Simple ECG May Help Distinguish MDD From Bipolar Depression

Higher low-frequency heart rate variability, lower levels of IL-10 and MCP-1 for major depression