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Esketamine seems to be efficacious and safe for patients with treatment-resistant depression

Esketamine Safe, Effective for Treatment-Resistant Depression

Change in Montgomery-Åsberg Depression Rating Scale score superior for esketamine versus placebo
Although patients with pre-existing autoimmune disease who receive checkpoint inhibitors (CPIs) are at risk for exacerbation of their disease

Immune-Related Adverse Events Up With Checkpoint Inhibitors

Most patients with cancer, autoimmune disease have improvement in events without discontinuing therapy
For patients with chronic obstructive pulmonary disease

CVD Risk Up With β2-Agonist, Antimuscarinic Antagonist Start

New use of long-acting β2-agonists, antimuscarinic antagonists tied to higher CVD risk in first 30 days
Improvement in obstetrician-gynecologists' knowledge and prescribing practices regarding opioids is needed

Improvement Needed in Ob-Gyn Opioid Prescribing Practices

Respondents prescribed median of 26 pills/patient; amount prescribed varied widely by indication
Dasiglucagon is well tolerated and is associated with an early pharmacodynamic response similar to that of GlucaGen for severe hypoglycemia

Dasiglucagon Well Tolerated for Severe Hypoglycemia

Early pharmacodynamic response similar to that of GlucaGen, with longer lasting effects plasma glucose
For patients with acute severe ulcerative colitis

Predictors of Infliximab Response in Ulcerative Colitis Identified

Baseline Mayo Endoscopic Score, CRP/albumin ratio predict treatment response and risk for colectomy
Few modern

Few Immuno-Oncology Agents Reach ASCO Efficacy Thresholds

Durable survival, response rates rarely recognized as significant by current oncology value frameworks
Pharmaceutical aids are not effective for increasing long-term smoking cessation

Pharmaceutical Aids Not Found to Be Helpful for Smoking Cessation

No evidence that varenicline, bupropion, or nicotine replacement increase probability of abstinence
From 2002 to 2015 there was a substantial increase in gabapentinoid use

Increase Seen in Gabapentinoid Use From 2002 to 2015

More than three-fold increase in percentage of adults using gabapentin and/or pregabalin

December 2017 Briefing – Pharmacy

Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for December 2017. This roundup includes the latest...