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A new drug to treat early Alzheimer disease will be submitted to the U.S. Food and Drug Administration for approval

New Alzheimer Disease Drug to Be Submitted for FDA Approval

New analysis of study results suggests highest dose of aducanumab may help slow cognitive decline
There will be more health insurance choices and a slight decrease in premiums for many consumers next year under the Affordable Care Act

More Choices, Lower Premiums for ACA Consumers Next Year

20 more insurers will be participating in 2020, expanding consumer choice in many states
Opioids are commonly not needed but are overprescribed at discharge among women who undergo cesarean deliveries (CDs)

ASA: Unnecessary Opioids Often Prescribed After C-Section

Change in computerized order sets reduces use of oxycodone to treat pain after cesarean delivery
Among patients with mild-to-moderate acute traumatic brain injury

Tranexamic Acid Within Three Hours Cuts Some TBI Deaths

Patients with mild-to-moderate injury treated with tranexamic acid had reduced risk for head injury-related death
For patients with chronic obstructive pulmonary disease

CHEST: Metoprolol Does Not Cut Time to COPD Exacerbation

Trial stopped early due to futility with respect to primary end point and safety concerns
The over-the-counter heartburn drug Zantac (ranitidine) has been recalled in the United States and Canada by French drug maker Sanofi.

Zantac Recalled by Sanofi

FDA has warned that some versions of the drug contain low levels of N-nitrosodimethylamine
In clinical guidelines published online Oct. 22 in the Annals of Internal Medicine

Recommendations Updated for Nonvariceal Upper GI Bleeding

Guidelines address preendoscopic, endoscopic, and pharmacologic management
For patients with metastatic breast cancer

Patient Cost Responsibility Up for Guideline-Discordant Care

Guideline-discordant tx linked to $1,841 higher patient costs in first year in metastatic breast cancer
For patients with knee osteoarthritis

Physical Therapy, Lifestyle Advice Underused in Knee OA

2007 to 2015 saw increase in use of NSAID prescriptions from orthopedists, primary care doctors
Among individuals aged 66 years and older

Suicide Risk Up With ARB Exposure Versus ACEI Exposure

Risk for suicide increased with angiotensin receptor blockers among individuals aged 66 years and older