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Breakdown of the blood-brain barrier may be an early biomarker of cognitive dysfunction

Breakdown of Blood-Brain Barrier May Drive Dementia

Leaky brain capillaries tied to cognitive dysfunction, independent of protein markers for dementia
Ethical principles are discussed in an updated Ethics Manual

American College of Physicians Releases 7th Edition of Ethics Manual

Manual focuses on patient-physician relationship in different scenarios, including telemedicine
Patients with Tourette syndrome or chronic tic disorder have an increased risk for developing at least one metabolic or cardiovascular disorder

Cardiometabolic Risk Up With Tourette, Chronic Tic Disorder

Higher risks seen for obesity, type 2 diabetes, circulatory system diseases
The influence of heritability and environmental factors has been identified for a large number of phenotypes

Study Explores Influence of Genetics, Environment in Disease

Genetic component for 40 percent of phenotypes studied; 25 percent have environmental risk factors
Among individuals with posttraumatic stress disorder

Terrorist Attack Victims With PTSD Have Higher Cancer Risk

Women with PTSD have higher risk for cancer than men, are more protected from circulatory issues
Eighteen percent of patients with back pain experience a persistent trajectory

One in Five Back Pain Patients Experience Persistent Pain

Significant differences seen in patterns of medication, health care use across back pain trajectories
The difference in health spending between the United States and other countries is still explained by health care prices

Prices Still Explain High U.S. Health Care Spending

Health care prices explain difference in spending between United States and other countries
The phenomenon of private equity acquisition of physician practices is discussed in an Ideas and Opinions piece published online Jan. 8 in the Annals of Internal Medicine.

Private Equity Acquisition of Physician Practices Discussed

Critics warn private equity firms might focus on increased profitability at expense of patient care
Older people who have less slow wave sleep have higher levels of the brain protein tau

Less Deep Sleep in Elderly Tied to Alzheimer Disease Markers

Poor-quality sleep in later life could be a noninvasive marker for deteriorating brain health
The costs of oral and injectable brand-name drugs increased from 2008 to 2016

Increase in Brand-Name Drug Cost Mainly Due to Existing Drugs

Rising costs of oral, injectable generic and specialty drugs mostly driven by new product entry