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Hematology and Oncology

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A gene expression profile test to predict risk of breast cancer recurrence is less cost-effective in real-world practice as compared to ideal conditions

Breast Cancer Genetic Test Less Cost-Effective in Actual Practice

Oncotype DX less cost-effective in real-world practice than under ideal conditions
A multi-analyte blood test

Blood Test Found to Detect Eight Common Cancer Types

Sensitivities of 69 to 98 percent for detecting ovary, liver, stomach, pancreas, esophagus cancers
The elimination of cost sharing for screening mammography is associated with increased rates of use of the service

Screening Mammography Up After Cost Sharing Eliminated

Effect attenuated in women living in areas with lower educational levels; negligible for Hispanic women
National Health Service England recently recommended that professionals ask all patients their sexual orientation at every opportunity

Professionals Disagree About Asking Patients About Sexuality

Article offers opposing views about recommendation in England to ask patients about sexual orientation
High adherence to the Mediterranean diet is associated with a lower risk of aggressive prostate cancer

Mediterranean Diet May Lower Risk of Aggressive Prostate CA

Prudent or Western pattern diets had no association with prostate cancer risk
Overall

Nearly 30 Percent of Veterans Report Current Tobacco Use

Higher current use of tobacco products for those aged 18 to 25 years, Hispanics, those with low income
Patients with desmoplastic melanoma have a high level of objective tumor response to treatment with antibodies to block programmed cell death 1 (PD-1) or PD-1 ligand

High Response of Desmoplastic Melanomas to PD-1 Blockade

Higher percentage of PD-L1-positive cells in the tumor parenchyma of desmoplastic melanomas
Liquid biopsy that identifies circulating tumor cells in a blood sample has high accuracy for detecting colorectal cancer

ASCO: Liquid Biopsy Accurate for Detecting Colorectal Cancer

Novel assay to detect circulating tumor cells has high sensitivity, specificity for precancerous lesions
Elevation in white blood cell BRCA1 promoter methylation is associated with high-grade serous ovarian cancer

BRCA1 Promoter Methylation Tied to High-Grade Serous Ovarian CA

Elevated normal tissue BRCA1 promoter methylation associated with high-grade serous ovarian CA risk
Patients with myeloproliferative neoplasms (MPNs) have increased risk of arterial thrombosis and venous thrombosis across all age groups and MPN subtypes

Increased Risk of Thrombosis in Myeloproliferative Neoplasms

Higher rates of thrombosis compared to matched controls; risk highest at and soon after diagnosis