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May 2019 Briefing – Gastroenterology

Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for May 2019. This roundup includes the latest...
For frail and elderly patients with advanced gastroesophageal cancer

ASCO: Low-Dose Chemo Benefits Advanced Gastroesophageal Cancer

Elderly, frail receiving 60 percent of oxaliplatin/capecitabine dose have noninferior PFS, less toxicity
Pembrolizumab is noninferior to chemotherapy for overall survival among patients with programmed death ligand 1

ASCO: Pembrolizumab Noninferior to Chemo in Advanced Gastric Cancer

For patients with PD-L1 combined positive score of ≥10, pembrolizumab prolongs overall survival
Providing assistance for physician impairment and rehabilitation is addressed in a position statement issued by the American College of Physicians and published online June 4 in the Annals of Internal Medicine.

ACP Issues Position on Response to Physician Impairment

Rehabilitated doctors should be reintegrated into practice as long as patient safety not compromised
Clinical manifestations of systemic lupus erythematosus vary by racial and ethnic groups

Lupus Manifestations Appear to Differ by Race, Ethnicity

Increased risk for severe manifestations seen among blacks, Hispanics, and Asians/Pacific Islanders
Taking proton pump inhibitors is associated with an excess of cause-specific mortality

Excess Cause-Specific Mortality Tied to Chronic Proton Pump Inhibitor Use

Excess mortality due to CVD, CKD, upper GI cancer for those with no indication for PPI use
High costs are associated with physician turnover and reduced clinical hours attributed to burnout

High Costs Associated With Physician Burnout in U.S.

Nationally, about $4.6 billion in costs are related to physician turnover, reduced clinical hours
Whites in Western states are experiencing the most rapid increase in early-onset colorectal cancer

Early-Onset CRC Rising Fastest for Whites in Western States

Neither increases in prevalence of obesity nor heavy alcohol consumption correlated with CRC trends
Reading clinical notes can help patients to understand why medications are prescribed and improves medication adherence for some patients

Reading Visit Notes May Improve Medication Management

Patients say note reading helps them understand why meds are prescribed, makes them feel in control
The global burden of serious health-related suffering is set to increase 47 percent by 2060

Global Burden of Serious Health-Related Suffering to Double by 2060

Fastest increases seen in low-income countries, among older people, and for those with dementia