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Methylation of a gene panel is a strong predictor of survival outcomes in metastatic breast cancer

Methylation of Gene Panel May Help Predict Breast CA Survival

High cumulative methylation index linked to shorter median progression-free, overall survival
Circulating exosomes released under intermittent hypoxia conditions

Intermittent Hypoxia Promotes Lung Tumor Cell Aggressiveness

IH-induced exosomes from mice significantly promote TC1 malignant properties
An updated index incorporating gene and molecular alterations can predict survival in non-small-cell lung cancer with brain metastases

Updated Index Predicts Survival in NSCLC With Brain Metastases

Significant prognostic factors include four factors from earlier index, plus EGFR and ALK alterations
In guidelines published online Nov. 14 in the Journal of Clinical Oncology

Guidelines Developed for HER2 Testing in Gastroesophageal CA

Tumor specimens should be assessed for HER2 status before initiation of HER2-targeted therapy
Genetic variations correlate with mortality in the elderly

Genetic Mortality Risk Can Be Attenuated by Lifestyle

Mortality up to 64 percent lower for those with low-risk lifestyle profile, independent of genetic risk
BACH2 is a major risk locus for Addison's disease

BACH2 Identified As Risk Locus for Addison’s Disease

Extended exome capture array shows BACH2 correlates with Addison's disease development
Tobacco smoking causes mutations that lead to cancer by multiple distinct mechanisms

Smoking Ups Cancer Risk by Causing Distinct Cell Mutations

For every year of smoking a pack daily, 150 more mutations found in each lung cell
Genetic testing could help identify breast cancer patients at high risk for venous thromboembolism

Genetic Testing May Help ID VTE Risk in Breast Cancer Patients

Older breast cancer patients with increased genetic susceptibility receiving chemo have highest risk
Gene therapy shows promise in treating recessive dystrophic epidermolysis bullosa

Gene Tx Promising in Recessive Dystrophic Epidermolysis Bullosa

Grafts of patients' genetically modified skin improved healing of wounds in early study
Healthy living can lower the odds for colorectal cancer for men who are at high genetic risk for the disease

Men With Genetic Risk of CRC May Lower Risk Via Healthy Lifestyle

Adopting healthy lifestyle can cut 25-year risk for the disease from 29 to 13 percent