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Crohn's disease appears to have at least two distinct genetic subtypes

Two Genetic Subtypes of Crohn’s Disease Identified

Findings may help explain why the disease is so tough to treat, researchers say
An increase in systolic blood pressure due to genetic variants is associated with increased risk of type 2 diabetes

Genetic Increase in SBP Linked to Risk of Type 2 Diabetes

1 mm Hg elevation of SBP levels due to genetic score linked to increased risk of type 2 diabetes
Pembrolizumab is associated with longer progression-free and overall survival for patients with non-small-cell lung cancer with programmed death ligand 1 expression on at least 50 percent of tumor cells

Pembrolizumab Ups Survival in NSCLC With PD-L1 Expression

Findings in patients with advanced NSCLC with PD-L1 expression on at least 50 percent of tumor cells
A potential genetic link to a child's higher risk of acute otitis media has been identified

Gene Associated With Risk of Acute Otitis Media

Finding could point to better treatments
Low-density lipoprotein cholesterol-lowering genetic variants are associated with increased risk of type 2 diabetes

Exposure to LDL-C-Lowering Genetic Variants Ups T2DM Risk

Meta-analysis shows heterogeneous associations for genes in or near NPC1L1 with type 2 diabetes
In germ cell tumors

TP53, MDM2 Alterations Linked to Cisplatin Resistance in GCT

TP53, MDM2 alterations predict adverse prognosis in patients with germ cell tumors
Patients with the FTO gene respond to weight-loss strategies as well as those without the gene

FTO Gene Does Not Inhibit Weight Loss Success

Lifestyle, environment likely play bigger roles when losing weight, researchers say
Pevonedistat

Experimental Drug Shows Promise in Melanoma

Pevonedistat was effective for inhibiting proliferation of melanoma cell lines in vitro
Fibroblast growth factor 21 genotypes may interact with dietary macronutrient intake to affect central adiposity and body fat composition

FGF21, Dietary Intake Interaction Impacts Adiposity

FGF21 genotype interacts with dietary carbohydrate/fat intake to affect adiposity, body fat
The original classifications of human epidermal growth factor receptor 2 categorization by fluorescent in situ hybridization have been supported by recent data

Novel Findings Support Original Categorization of HER2

ASCO-CAP guidelines support categorization of HER2 by FISH status used in BCIRG clinical trials