Tag: Genetics
CRC in Patients Under 50 Often Caused by Genetic Mutations
One in six diagnosed under 50 have at least one gene mutation that ups risk of cancer
BRCA1/2, ATM Mutations ID Risk for Lethal Prostate Cancer
After adjustment for covariates, mutation carrier remained independent predictor of lethal PCa
BRCA Testing, Not Mastectomies, Up After Angelina Jolie Editorial
More women tested for the BRCA genes but no corresponding increase in mastectomy rates
Methylation of PITX2 DNA Feasible in Prostate Biopsies
Can add prognostic information for risk assessment in presurgical diagnostic setting
Cytotoxic T-Cells Can Induce Metastatic CRC Regression
Regression of tumors reported after administration of cytotoxic T-cells targeting mutant KRAS G12D
ASH: Single Dose of Gene Therapy Effective in Hemophilia B
Small, preliminary trial suggests it may free hemophilia B patients from transfusions
Functionally ID’d Variants in HNF1A Linked to Diabetes Risk
Functionally characterized variants that reduce HNF-1A transcriptional activity strongly linked to diabetes
Similar Effects for PCSK9, HMGCR Variant-Mediated Lower LDL
Almost equivalent effects on cardiovascular events, diabetes per unit decrease in LDL-cholesterol level
Gene Mutation Linked to Early-Onset Parkinson’s Disease
Mutated GCH1 gene tied to 23 percent increased risk of Parkinson's; symptoms five years earlier
Methylation of Gene Panel May Help Predict Breast CA Survival
High cumulative methylation index linked to shorter median progression-free, overall survival
