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A U.S. Food and Drug Administration safety announcement relating to atrial fibrillation risk associated with bisphosphonates correlated with a reduction in bisphosphonate use

FDA Safety Announcement Affected Bisphosphonate Use

Four percent decrease in odds of bisphosphonate use each quarter after safety announcement for a-fib risk
Fewer than half of atrial fibrillation patients at highest risk for stroke are prescribed recommended anticoagulation

Many A-Fib Patients Missing Out on Recommended Anticoagulation

Less than half at highest risk take recommended anticoagulants
In U.S. adolescents

Off-Label Use of Metformin Common in U.S. Adolescents

Analyses of three databases show use for metabolic syndrome, PCOS, and obesity
A new advisory

CDC Issues New Prescription Guidelines for Opioids

To curb abuse, doctors should try non-opioid options for chronic pain not involving cancer, terminal illness
Trends indicate a reduction in glyburide and thiazolidinedione prescriptions and increases in gliclazide and dipeptidyl peptidase-4 inhibitor prescriptions among older adults with diabetes and chronic kidney disease

Antihyperglycemic Medication Prescribing Trends Are Changing

Decrease in glyburide and thiazolidinedione Rx; increase in gliclazide, dipeptidyl peptidase-4 inhibitor
For patients with chronic calcific pancreatitis

Antioxidant-Pregabalin Cuts Pain in Chronic Calcific Pancreatitis

Randomized trial shows significant pain reduction for patients with chronic calcific pancreatitis
A combined intervention of optimized analgesic prescription and exercise therapy is feasible and associated with significant reductions in pain and activity limitation in patients with knee osteoarthritis and severe knee pain

Analgesics Plus Exercise Therapy Feasible for Knee OA

Seventy-eight percent of patients could participate in exercise protocol after analgesic use
About 25 percent of patients with infantile hemangioma have rebound growth

Rebound Growth for One in Four With Infantile Hemangioma

Factors linked to rebound growth include age of discontinuation, deep IH, and female gender
Warfarin treatment for patients with atrial fibrillation may raise the risk of traumatic intracranial bleeding by more than previously reported

Warfarin’s Intracranial Bleed Risk Higher Than Previously Reported

Several factors place patients at increased risk of traumatic intracranial bleeding
A combination drug therapy widely used to treat malaria in adults -- dihydroartemisinin-piperaquine -- also protects pregnant women and their fetuses from the disease

Combo Tx Protects Pregnant Women, Fetuses From Malaria

Findings suggest older medication is losing effectiveness, researchers say