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For patients with dementia with Lewy bodies

Adjunct Zonisamide Beneficial in Dementia With Lewy Bodies

Zonisamide as an adjunct to levodopa improves parkinsonism without worsening cognitive function
Prior authorization requirements are greater for proprotein convertase subtilisin/kexin type 9 inhibitors than for other cardiometabolic drugs

Greater Prior Authorization Requirements Seen for PCSK9i Rx

PA requirements are more extensive for PCSK9is than for other cardiometabolic drugs
Doxylamine-pyridoxine may be beneficial for nausea and vomiting symptoms in early pregnancy

Value of Doxylamine-Pyridoxine Questioned in Early Pregnancy

Greater improvement in symptom scores versus placebo, but clinical relevance unclear
A case of remission of psoriasis after treatment of chronic hepatitis C virus has been described in a research letter published online Jan. 16 in the Annals of Internal Medicine.

Psoriasis Remission Described After Hepatitis C Virus Treatment

Case report: After initiation of ledipasvir-sofosbuvir, HCV RNA decreased, and skin lesions improved
Patients with desmoplastic melanoma have a high level of objective tumor response to treatment with antibodies to block programmed cell death 1 (PD-1) or PD-1 ligand

High Response of Desmoplastic Melanomas to PD-1 Blockade

Higher percentage of PD-L1-positive cells in the tumor parenchyma of desmoplastic melanomas
Rituximab has better efficacy and lower discontinuation rates than other disease-modifying treatment choices for newly diagnosed relapsing-remitting multiple sclerosis

Rituximab Tops Other Disease-Modifying Tx Options in MS

Better efficacy, lower discontinuation rate in newly diagnosed relapsing-remitting multiple sclerosis
The use of idalopirdine does not improve cognition versus placebo over 24 weeks of treatment for patients with mild-to-moderate Alzheimer's disease

Idalopirdine May Not Improve Cognition in Mild Alzheimer’s

Findings from three randomized trials show no improvement in cognition vs. placebo over 24 weeks
A novel oral dosage form enables sustained release of antiretrovirals

Week’s Worth of HIV Meds in a Single-Dose Capsule Feasible

Oral platform delivers three antiretrovirals for up to seven days after single administration
Fluorouracil application can reduce the risk of surgery for squamous cell carcinoma for one year among patients with a history of keratinocyte carcinomas

Fluorouracil Tied to Reduced Surgery for Squamous Cell CA

Reduced risk of squamous cell carcinoma, but not basal cell carcinoma, for one year in at-risk veterans
Esketamine seems to be efficacious and safe for patients with treatment-resistant depression

Esketamine Safe, Effective for Treatment-Resistant Depression

Change in Montgomery-Åsberg Depression Rating Scale score superior for esketamine versus placebo