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Tag: Heartburn / GERD / Indigestion

Diaphragmatic breathing can reduce belching and proton pump inhibitor-refractory gastroesophageal reflux

Diaphragmatic Breathing Tied to Less Belching in GERD

The therapy is associated with reduced symptoms in patients with PPI-refractory gastroesophageal reflux
Gastroesophageal reflux disease is associated with a higher risk of cancer in the upper aerodigestive tract among the elderly population in the United States

GERD Linked to Upper Aerodigestive Tract Cancers

In elderly, tied to higher odds of malignancy in larynx, hypopharynx, oropharynx, nasopharynx
Children with CYP2C19*17 alleles without corresponding loss-of-function alleles have longer times with pH <4 in response to proton pump inhibitor medication

CYPC19*17 Allele May Influence Response to PPI Treatment

Kids with CYPC19&#42;17 alleles without corresponding loss-of-function alleles have longer times with pH &#60;4
Laparoscopic antireflux surgery is associated with a relatively high rate of recurrent gastroesophageal reflux disease

Antireflux Surgery Has High Rate of Recurrent Disease

Nearly 18 percent have recurrence requiring long-term medication, secondary surgery
For infants with gastroesophageal reflux disease

Variation in Management for Infants With GERD

Variation in overall utilization of anti-reflux surgery, and in surgical and diagnostic approach
For patients with gastroesophageal reflux disease

HRQoL Down for GERD With Laryngopharyngeal Reflux

Significantly lower mean EuroQoL-5D scores for gastroesophageal reflux disease with LPR symptoms
For patients with gastroesophageal reflux disease

Sleep Disturbance Linked to Esophageal Hypersensitivity

Patients with sleep disturbance have enhanced heartburn perception to capsaicin infusion
Thirty-seven percent of premature infants receive gastroesophageal reflux medications

Preemies Often Receive Gastroesophageal Reflux Meds

Seventy-seven percent of those on medications started after NICU discharge; prolonged use common
Epithelial thickness seems to be a marker for gastroesophageal reflux disease

Epithelial Thickness Is Marker for Gastroesophageal Reflux

Epithelial thickness is best performing criterion for GERD diagnosis in patients with upper GI symptoms
Advice of regulatory authorities released in 2009 and 2010 regarding safety concerns for concomitant use of clopidogrel and certain proton pump inhibitors (PPIs) was partially followed

Many Still Prescribe Concomitant (Es)omeprazole, Clopidogrel

Patients on clopidogrel prescribed omeprazole or esomeprazole despite safety warnings