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Current practice patterns relating to testing and management of thyroid-stimulating hormone during pregnancy are associated with overdiagnosis and overtreatment of hypothyroidism

Thyroid Dysfunction in Pregnancy Overdiagnosed, Overtreated

In most women with elevated TSH who did not start treatment, repeat measurement was ≤4.00 mIU/L
L-thyroxine does not improve hypothyroid symptoms or tiredness among older adults with subclinical hypothyroidism and high symptom burden

L-Thyroxine Does Not Improve Subclinical Hypothyroidism in ≥65s

No improvement seen in hypothyroid symptoms, tiredness versus placebo in older adults with SCH
A minor planned decrease in the upper limit of the reference range for thyroid-stimulating hormone (TSH) resulted in an increase in levothyroxine prescriptions and more TSH measurements

Testing, Prescribing Increase After Change to TSH Reference Range

Levothyroxine prescriptions, TSH measurements increased after upper limit of normal for TSH lowered
Synthetic levothyroxine is associated with an increased risk for death among older adults

ENDO: Thyroid Hormone Use May Up Mortality Risk in Older Adults

Increased risk for death seen for visits on LT4 versus those with isolated elevated TSH who were untreated
In a summary of a recent guideline from the National Institute for Health and Care Excellence

NICE Guidelines Presented for Management of Thyroid Disease

For thyrotoxicosis with hyperthyroidism, radioactive iodine recommended as first-line treatment
In guidelines issued by the American Association of Endocrine Surgeons

Recommendations Developed for Appropriate Thyroidectomy

Guidelines relate to diagnosis of thyroid disease, indications for thyroidectomy, periop management
While the rate of thyroid dysfunction among patients with psoriasis generally is not higher than expected

Inflammation Linked to Thyroid Dysfunction in Psoriasis Patients

Patients with thyroid dysfunction and psoriasis have higher serum C-reactive protein levels
Hypothyroidism is significantly associated with increased all-cause mortality

Overt Hypothyroidism May Up All-Cause Mortality in the Elderly

However, no association seen between hypothyroidism and cardiovascular mortality
About 6 percent of psychiatrically hospitalized youth have abnormal thyroid-stimulating hormone measures

TSH Elevated in 6 Percent of Psychiatrically Hospitalized Youth

Elevated thyroid-stimulating hormone linked to recent weight gain, treatment with benzodiazepines
For patients undergoing total thyroidectomy

Thyroidectomy Complication Rate Down When Surgeon Volume Up

Statistically significant decreases in complication rates, but absolute decreases were low