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Tag: Sickle-Cell Anemia

Trial of Gene Therapy for Sickle Cell Disease Halted

Two patients participating in the study developed cancer years after treatment

Broader Genetic Testing Could ID More Heritable Cancers

ASH: CRISPR-Cas9 Gene Editing Promising in TDT, SCD

Total hemoglobin, fetal Hb increased in seven patients with transfusion-dependent ß-thalassemia, three with sickle cell disease

Broader Genetic Testing Could ID More Heritable Cancers

ASH: CRISPR-Cas9 Gene Editing Promising in TDT, SCD

Total hemoglobin, fetal Hb increased in five patients with transfusion-dependent ß-thalassemia, two with sickle cell disease

Use of medical marijuana is associated with fewer hospitalizations among patients with sickle cell disease

Medical Marijuana Tied to Fewer Admissions in Sickle Cell Disease

But no change in opioid use observed for those receiving medical marijuana certification
Endurance exercise training may improve skeletal muscle microvasculature in patients with sickle cell disease

Endurance Exercise May Offer Vascular Benefit in Sickle Cell Disease

Increases in capillary density, functional exchange surface seen in microvasculature of skeletal muscle
A U.S. clinical trial of CRISPR gene-editing to treat people with sickle cell disease is underway.

Trial Tests CRISPR Gene-Editing to Treat Sickle Cell Disease

Study seeks to recruit up to 45 adults with severe sickle cell disease
For individuals with sickle cell disease

Voxelotor Improves Hemoglobin Levels in Sickle Cell Disease

Fewer individuals in voxelotor group versus placebo group have worsened anemia at week 24
For patients with severe hemoglobinopathies undergoing bone marrow transplantation

Increasing Dose for Total Body Irradiation Cuts Graft Failure

Findings seen in patients with severe hemoglobinopathies receiving haploidentical bone marrow transplantation
A sickle cell disease prevention and treatment program in the United States has been reauthorized to receive nearly $5 million each year over the next five years.

New Law Boosts Fight Against Sickle Cell Disease

In 2018, the National Institutes of Health was funded approximately $115 million for research of the disease
For patients with sickle cell-related pain

L-Glutamine Reduces Number of Pain Crises in Sickle Cell Disease

Significantly fewer pain crises, hospitalizations compared with those receiving placebo