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Lisinopril therapy is associated with a significant reduction in incident conduction system disease

Lisinopril Therapy Cuts Incident Conduction System Disease

Factors independently associated with disease include increased age, male sex, white race, diabetes
The experimental drug midostaurin may reverse organ damage in patients with advanced systemic mastocytosis

Midostaurin Beneficial in Advanced Systemic Mastocytosis

Organ damage improved in 60 percent of patients with advanced systemic mastocytosis
Certain cancer immunotherapy drugs may increase risk for rheumatic disease

Cancer Immunotherapy May Induce Arthritis, Sicca Syndrome

Findings with ipilimumab (anti-CTLA-4) and/or nivolumab (anti-PD-1) for solid tumors
In older adults

Depression Cuts Adherence to COPD Maintenance Meds

Average monthly adherence to COPD maintenance medications low in older adults
Pharmacy programs to reduce opioid abuse are effective but underused

Pharmacy Programs to ID Opioid Abuse Effective, but Underused

Monitoring program in Maine was only used by 56 percent of pharmacists
For patients with minor ischemic stroke or transient ischemic attack

Clopidogrel Plus Aspirin Good for Noncarriers of CYP2C19 Variants

Reduction in risk of new stroke for clopidogrel plus aspirin in those not carrying loss-of-function alleles
Patients on long-term opioid therapy who receive prescriptions for naloxone are less likely to return for emergency care related to opioid use

Coprescribing Naloxone to Opioid Users Helps Reduce ER Visits

Finding supports naloxone prescriptions for patients taking opioids for chronic pain
For patients with type 2 diabetes taking metformin

Liraglutide Tops Lixisenatide As Add-On to Metformin in T2DM

Greater reduction in hemoglobin A1c, greater reduction in fasting plasma glucose with liraglutide
In patients with early breast cancer

Candesartan Doesn’t Prevent Trastuzumab Cardiotoxicity

Cumulative incidence of cardiac events not significantly different with candesartan, placebo