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Children of first-cousin consanguineous parents are more likely to be in receipt of antidepressant or anxiolytic medications and antipsychotic medications

Mood Disorders Up for Children of Consanguineous Parents

Increased odds of mental health issues and needing antidepressant, anxiolytic, antipsychotic medications
There is considerable variation in the quality of free-text patient directions in electronic prescriptions

Variations Identified in Free-Text Directions in E-Prescriptions

However, more than half of all prescriber's patient directions could be categorized into 25 concepts
Using CYP2C19 genotype-guided dual antiplatelet therapy selection is feasible in a real-world setting

Genotype-Guided Antiplatelet Therapy Feasible, Effective

Genotype-guided therapy improves outcomes among CYP2C19 intermediate, poor metabolizers
Outcomes-based pricing does not reduce the costs of proprotein convertase subtilisin/kexin type 9 inhibitors

Outcomes-Based Pricing Doesn’t Cut Costs of PCSK9 Inhibitors

Incremental cost-effectiveness ratio for PCSK9 inhibitor improved marginally in three refund scenarios
For castration-resistant prostate cancer

Low-Dose Abiraterone Acetate Noninferior for Prostate Cancer

Low-dose AA with low-fat breakfast had greater effect on PSA; similar effect to standard dose
Exposure to sodium valproate or a combination of antiepileptic drugs in utero is associated with worse attainment on national educational tests for 7-year-olds

Educational Attainment Down With In Utero Exposure to AEDs

Exposure to sodium valproate, combo of antiepileptic drugs tied to worse attainment on national tests
Intravitreal anti-vascular endothelial growth factor treatment is not associated with increased risk of systemic adverse events for patients with neovascular age-related macular degeneration

Intravitreal Anti-VEGF Use Not Tied to Systemic Adverse Events

Risk not up in neovascular age-related macular degeneration, diabetic macular edema
For patients with previously untreated clear-cell advanced renal-cell carcinoma

Nivolumab Plus Ipilimumab Tops Sunitinib for Advanced Renal CA

Overall survival, objective response higher than sunitinib for untreated clear-cell advanced RCC
For patients with secondary progressive multiple sclerosis

Siponimod Cuts Risk of Disability Progression in Multiple Sclerosis

Reduction in 3-month confirmed disability progression in secondary progressive multiple sclerosis
Dipeptidyl peptidase-4 inhibitors are associated with increased risk of inflammatory bowel disease among patients with type 2 diabetes

Dipeptidyl Peptidase-4 Inhibitors in T2DM Linked to IBD

Higher risk of inflammatory bowel disease with longer use of dipeptidyl peptidase-4 inhibitor