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Tag: Insulin

For patients with type 2 diabetes mellitus treated with metformin

Add-On Sitagliptin Cuts Risk of Insulin Initiation in T2DM

Risk of insulin initiation lower for sitagliptin versus sulphonylurea as add-on to metformin
A closed-loop insulin delivery system can improve glucose control and reduce hypoglycemia in patients with type 1 diabetes

Positive Results for Home Use of Closed-Loop Insulin System

Positive findings for 12-week use of closed-loop system compared with sensor-augmented pump therapy
Overweight and obese adolescents have persistently higher homeostasis model assessment of insulin resistance

Sleep Affects HOMA-IR in Overweight, Obese Teens

Significant contributors include BMI z-score, age, pubertal stage, total sleep time, sleep efficiency
For patients with type 2 diabetes

Long-Acting Analog Insulin Doesn’t Up AMI Risk in T2DM

No significant difference in risk for long-acting analog, other basal insulin therapies
A higher homeostatic model assessment-insulin resistance index score may be an early marker for an increased risk of cognitive decline in women

Insulin Resistance Tied to Signs of Cognitive Decline in Women

Specifically, higher HOMA-IR score associated with poorer verbal fluency in women, but not in men
For individuals with type 1 diabetes

Long-Term Insulin Pump Use Reduces Mortality in T1DM

Long-term use of insulin pump reduces fatal coronary heart disease, CVD, all-cause mortality
Hippocampal insulin resistance may be a key mediator of cognitive deficits

Hippocampal Insulin Resistance Linked to Neuroplasticity

Rat model with hippocampal-specific insulin resistance downregulates insulin receptor expression
A microneedle-array patch ("smart insulin patch") containing glucose-responsive vesicles

‘Smart Insulin Patch’ Holds Promise for T1DM

Patch contains glucose-regulated vesicles, which are loaded with insulin, sensitive to hypoxia
Serum 25-hydroxyvitamin D3 is associated with glucose-stimulated insulin secretion and β-cell function in individuals with newly diagnosed type 2 diabetes

Low Serum 25(OH)D3 in Patients Newly Diagnosed With T2DM

Serum 25(OH)D3 linked to glucose-stimulated insulin secretion, β-cell function
For women with polycystic ovary syndrome

β-Cell Function Linked to Inflammation in PCOS

Research implicates inflammation in the impairment of β-cell function in PCOS