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Tag: Immune Disorders

For patients with autoimmune diseases

Zoster Ups Stroke Risk in Patients With Autoimmune Disease

For patients with autoimmune disease, herpes zoster tied to increased stroke risk in first 90 days
Hypoglycemia can promote mobilization of specific subsets of leukocytes and induce pro-inflammatory functional changes in immune cells

Hypoglycemia Induces Pro-Inflammatory Functional Changes

Increases numbers of leukocytes in healthy controls, patients with normal awareness of hypoglycemia
Mutant BCL11B has been identified as a cause of severe combined immunodeficiency in newborn screening

Newborn Screen IDs Previously Unknown Cause of SCID

Identification of missense mutation in BCL11B; immune deficit in infant corrected with HSCT

American College of Rheumatology, Nov. 12-16

The 80th Annual Meeting of the American College of Rheumatology The annual meeting of the American College of Rheumatology was held from Nov....
In a report published online Nov. 8 in Pediatrics

Report of Recurrent Immune Thrombocytopenia After Flu Shot

Case report describes 4.5-year-old with three admissions for ITP, each within a week of vaccine
The estimated prevalence of current immunosuppression is 2.7 percent among the U.S. population

ISDA: U.S. Prevalence of Immunosuppression 2.7 Percent

Prevalence ranged from 1.8 to 3.1 percent; highest among women, whites, those aged 50 to 59 years
Intravenous immunoglobulin is increasingly being used for interstitial lung disease

IV Immunoglobulin Use Up in Interstitial Lung Disease

No studies support use of IVIg in ILD, but increasingly being used off-label for refractory cases
For pediatric patients

Biologic Response Modifier Use in Kids Ups Infectious Complications

Risk varies with class of BRM; increased risk of mycobacterial, viral, fungal, opportunistic infections
Investigators describe a strategy for development of a broad-spectrum anti-viral agent. Their research was published online May 19 in Nature Communications.

ISG15 Deficiency Linked to Antiviral Immunity in Humans

In contrast to Isg15-deficient mice, deficient patients have no enhanced susceptibility to viruses
Rab3D and Rab27 proteins play an important role in the enhanced release of cathepsin S from lacrimal gland acinar cells in Sjögren's syndrome

New Insight Might Aid Diagnosis, Treatment of Sjögren’s Syndrome

Mouse model shows role for proteins in enhanced release of CTSS in Sjögren's syndrome patient tears