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Home Tags Heart / Stroke-Related: High Cholesterol

Tag: Heart / Stroke-Related: High Cholesterol

The diabetes drug metformin changes metabolic profiles of three metabolites that may lower LDL cholesterol

Metabolic Changes With Metformin May Lower LDL-C

Possible metabolic mechanism includes activation of AMPK, FADS suppression
At lower values of measured low-density lipoprotein cholesterol (LDL-C)

Calculated LDL-C Varies at Lower Values of Measured LDL-C

For calculated LDL-C of 30 mg/dL, 95 percent confidence interval was 24 to 60 mg/dL
Praluent (alirocumab) injection has been approved by the U.S. Food and Drug Administration for use in addition to diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease

FDA Approves Praluent for Certain Cases of High Cholesterol

First in a new class of injectable cholesterol-lowering medications
Updated guidelines for cholesterol management were released in 2013 by the American College of Cardiology and the American Heart Association. Now

New Guidelines Deemed Better for Identifying Statin Candidates

New guidelines would have 13 million more Americans taking the cholesterol drugs, experts say
A joint clinical practice guideline for the management of dyslipidemia for cardiovascular disease risk reduction in adults has been summarized and published online June 22 in the Annals of Internal Medicine.

VA/DoD Release Guidelines for Dyslipidemia Management

Key features include elimination of treatment targets, additional testing only when rationale clear
On Wednesday

FDA Panel Recommends Approval of Second PCSK9 Inhibitor

Evolocumab (Repatha) for use in patients at very high risk for high cholesterol
U.S. health experts voted on Tuesday to recommend approval of the first of two drugs in a new class of cholesterol medications that reduce low-density lipoprotein cholesterol in patients who don't fare well on statins. The related research was published online April 28 in the Annals of Internal Medicine.

FDA Panel Recommends Approval for PCSK9 Inhibitor

Could be used by patients who don't respond to statins
Older patients taking statins or fibrates saw their risk of stroke over almost a decade decline by about one-third

Statins, Fibrates Linked to 30% Lower Stroke Risk in Elderly

But no association between statins and lower risk of coronary heart disease in this group
Americans' levels of triglycerides have dropped significantly in the past decade

CDC: Triglyceride Levels Falling for Americans

But many people still at risk
Statin use does not lower the risk of psoriasis

Statins Don’t Reduce Psoriasis Risk

Findings among patients with high, long-term adherence to statins