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Tag: Cancer: Colon

Administration of cytotoxic T-cells targeting mutant KRAS G12D can induce tumor regression in metastatic colorectal cancer

Cytotoxic T-Cells Can Induce Metastatic CRC Regression

Regression of tumors reported after administration of cytotoxic T-cells targeting mutant KRAS G12D
Statins seem not to be associated with the risk of colorectal adenoma

Meta-Analysis: Statins Cut Risk of Advanced Colorectal Adenoma

In meta-analysis, statin use linked to reduced risk of advanced, but not any colorectal adenoma
Octamer-binding transcription factor 4 is a predictive marker for patients with digestive system cancers

Oct4 Found to Be a Prognostic Marker for Digestive Cancers

Elevated Oct4 levels tied to poor overall, disease-free, and recurrence-free survival
Regular aspirin use is associated with a lower risk of colorectal carcinomas with low concentrations of tumor infiltrating lymphocytes

Immune Response May Be Key to Chemopreventive Effect of Aspirin

Link seen for colorectal tumors with low levels of tumor infiltrating lymphocytes
Colorectal cancer detected after colonoscopy examination is more often located in the proximal colon and more likely to have DNA mismatch repair deficiency

CRC Detected After Colonoscopy Often Located in Proximal Colon

Tumors more likely to have DNA mismatch repair deficiency, less likely to be metastatic
Weight loss following chemically-induced carcinogenesis is not beneficial for colon and liver carcinogenesis in a mouse model that mimics human obesity

Weight Loss May Not Benefit Colon, Liver Cancer

In experimental study, no impact on colon tumorigenesis; may negatively impact liver repair
Colon capsule endoscopy (CCE)

Review: Colon Capsule Endoscopy Accurate in Polyp Detection

Second-generation CCE has high sensitivity and specificity for polyps >6 mm and >10 mm
The side of origin of colon cancer impacts prognosis

Review: Reduced Risk of Death for Left-Sided Colon Cancer

Significantly reduced risk of death, independent of confounding variables, including stage, race, chemo
Fecal immunochemical testing has advantages as a colorectal cancer screening method

Advantages of FIT As CRC Screening Method Discussed

FIT has several advantages over gFOBT, but practical concerns should be considered
Healthy living can lower the odds for colorectal cancer for men who are at high genetic risk for the disease

Men With Genetic Risk of CRC May Lower Risk Via Healthy Lifestyle

Adopting healthy lifestyle can cut 25-year risk for the disease from 29 to 13 percent