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Tag: Cancer: Cervical

Catch-up doses of quadrivalent human papillomavirus vaccination are effective for girls and women aged 14 to 20 years at the time of first dose

Catch-Up HPV Doses Effective to Age 21 Against Cervical Neoplasia

But catch-up doses not effective against CIN for women who initiated vaccination at 21 to 26 years
The U.S. Preventive Services Task Force has updated the recommendations for screening for cervical cancer; the final recommendation statement has been published in the Aug. 21 issue of the Journal of the American Medical Association.

USPSTF Updates Guidance for Cervical Cancer Screening

Cytology recommended every three years from age 21; different screening options from age 30 to 65
The use of primary human papillomavirus testing versus cytology results in reduced likelihood of cervical intraepithelial neoplasia grade 3 or worse at 48 months

HPV Cervical CA Screening Cuts Odds of Later CIN3+ Diagnosis

Use of primary HPV testing results in significantly lower odds of CIN3+ compared with cytology testing
Human papillomavirus vaccines protect against cervical precancer in adolescent girls and young women

Good Evidence That HPV Vaccines Protect Against Cervical Precancer

High-certainty evidence for protection in adolescent girls and young women aged 15 to 26 years
Diethylstilbestrol-related clear-cell adenocarcinoma of the vagina and cervix is associated with increased risk of death

Mortality Risk Persists for Cancer Tied to Prenatal DES Exposure

Women with DES-related clear-cell adenocarcinoma had 27-fold higher mortality at 10 to 34 years
A considerable proportion of women are diagnosed with cervical cancer after age 65

Cervical Cancer Frequently Diagnosed After Age 65

Almost 20 percent of cervical cancer cases are diagnosed in women older than 65
Most untreated cervical intraepithelial neoplasia grade 2 lesions regress

Many Untreated CIN2 Lesions Regress Spontaneously

Regression of cervical intraepithelial neoplasia grade 2 lesions especially likely in younger women
The five-year risks of cervical intraepithelial neoplasia grade 3 (CIN3)

Risk of ≥CIN3 Drops With Negative HPV, Cytology Co-Tests

Decrease in 5-year ≥CIN3 risks after each successive negative round of HPV, cytology co-testing
For patients with locally advanced cervical cancer

ASTRO: High-Dose Brachytherapy Effective With Four 7 Gy Fractions

Better tumor control than with two 9 Gy fractions among patients with locally advanced cervical cancer
The U.S. Preventive Services Task Force (USPSTF) recommends cervical cancer screening with cervical cytology alone every three years or screening with high-risk human papillomavirus testing alone every five years in women ages 30 to 65 years. These findings form the basis of a draft recommendation statement published online Sept. 12 by the USPSTF.

USPSTF Backs Cervical Cancer Screening With Cytology or hrHPV

Recommendations for screening with cytology alone every three years or hrHPV testing every five years