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Taking spironolactone alongside the antibiotic trimethoprim-sulfamethoxazole can cause blood potassium to rise to potentially life-threatening levels

Spironolactone + TMP-SMX May Up Risk of Sudden Death

Doctors urged not to prescribe spironolactone with trimethoprim-sulfamethoxazole
High penicillin G prescribing may lead to an altered level of resistance in the commensal viridans group streptococci population

High Penicillin Prescribing Could Build Reservoirs of Resistance

Significant difference in minimum inhibitory concentration for high, low prescribers of penicillin G
Utilization patterns indicate that antimicrobial prophylaxis is overused for urological surgeries in the community practice setting

Prophylactic Antimicrobials Overused in Urologic Surgery

In community practice, overall rate of compliance with AUA Best Practices is less than 60 percent
The overuse of antibiotics to treat travelers' diarrhea may contribute to the spread of drug-resistant superbugs

Overuse of Abx for Travelers’ Diarrhea Creating Superbugs

Researchers recommend caution when using antibiotics to treat digestive ills while abroad
For children with community-acquired pneumonia

No Negative Consequences of Guidelines for Antibiotic Therapy

No change in length of stay, total costs, inpatient pharmacy costs among children with pneumonia