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A new vaccine for herpes simplex virus type 2 could be nearing human clinical trials

Early Study Results Promising for Genital Herpes Vaccine

Two-pronged approach tested on lab monkeys, guinea pigs
An experimental drug

Experimental Drug May Simplify Macular Degeneration Treatment

Animal tests showed fewer injections needed to treat age-related macular degeneration
Scientists are reporting some early success with a soft robotic device aimed at treating advanced heart failure. The findings have been published in the Jan. 18 issue of Science Translational Medicine.

Soft Robotic Sleeve Can Replicate Heart’s Natural Rhythm

Device found to support heart function in a porcine model of acute heart failure
The amplitude of therapeutic revascularization associated with recombinant adeno-associated virus (5 × 1012 viral particles encoding thymosin beta 4) is reduced with diabetes mellitus

Diabetes May Impair Myocardial Proangiogenic Response

Reduction in amplitude of therapeutic neovascularization via rAAV.Tβ4 in pig model
Ivermectin has anti-inflammatory properties that could be beneficial in treatment of T-cell mediated skin inflammatory diseases

Ivermectin Has Topical Anti-Inflammatory Properties

Topical ivermectin improves allergic skin inflammation in murine model of atopic dermatitis
For midlife ovariectomized Long Evans rats

Duration of Estrogen Rx May Be Important Factor in Renal Health

Long-term estradiol treatment induced renal and cardiac hypertrophy, reduced glomerular filtration
Vaginal tissue is particularly vulnerable to infection by RNA viruses

Vaginal Immune Response May Up Zika Risk in Women

Findings suggest, when transmitted sexually, women are more susceptible to contracting RNA viruses
Animal research with an experimental two-drug therapy could hold clues for creating long-term HIV remission

Two-Drug Combo Promising for HIV Remission

Combination includes an HIV vaccine and an immune-stimulating drug
Weight loss following chemically-induced carcinogenesis is not beneficial for colon and liver carcinogenesis in a mouse model that mimics human obesity

Weight Loss May Not Benefit Colon, Liver Cancer

In experimental study, no impact on colon tumorigenesis; may negatively impact liver repair
Total body irradiation alters intracellular signaling and epigenetic pathways regulating cell proliferation and differentiation of skeletal muscle and adipose progenitor cells

Radiation Effect on Epigenetic Modifiers May Up Metabolic Risk

Insulin signaling chronically disrupted in skeletal muscle, adipose progenitor cells from irradiated mice