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Monthly Archives: December 2019

Sleep fragmentation

Sleep Fragmentation Linked to Odds of Migraine

No temporal association found for short sleep duration, low sleep quality with migraine
Long working hours are an independent risk factor for masked and sustained hypertension

Long Working Hours May Up Risk for Masked, Sustained HTN

Working 49+ hours/week associated with increased prevalence of masked, sustained hypertension
Men born small for gestational age may have an increased risk for infertility in adulthood

Infertility Risk Increased for Men Born Small for Gestational Age

Link weakened after excluding those born with hypospadias, cryptorchidism; no link seen in women
For critically ill

Vitamin D Supplementation Offers No Benefit for Critically Ill

Among critically ill patients with vitamin D deficiency, supplementation did not improve 90-day mortality
Aspirin may not be effective for primary prevention of cardiovascular disease and cancer mortality

Aspirin May No Longer Have Effect in Primary CVD Prevention

Also no significant decrease seen in cancer death in studies from 2005 onward
Hypothyroidism is significantly associated with increased all-cause mortality

Overt Hypothyroidism May Up All-Cause Mortality in the Elderly

However, no association seen between hypothyroidism and cardiovascular mortality
Among patients with metastatic renal cell carcinoma

Tivozanib Bests Sorafenib in Metastatic Renal Cell Carcinoma

Progression-free survival longer in those receiving tivozanib as third- or fourth-line therapy
Supplementation with vitamin D alone does not appear to reduce the risk for fracture

Vitamin D Supplementation Alone May Not Reduce Fracture Risk

However, meta-analysis shows significant reduction in any, hip fracture with vitamin D plus calcium
The rate of opioid-related suicides as well as unintentional deaths significantly increased from 2000 to 2017

Opioid-Related Suicides Down, Rate of Unintentional Deaths Up

Crises of opioid overdose deaths and suicide do not appear closely linked
The first Ebola vaccine approved by the U.S. Food and Drug Administration is a single-dose injection called Ervebo. The vaccine from Merck & Co. is approved to protect against the Zaire ebolavirus in people ages 18 years and older.

FDA Gives First Ebola Vaccine for Adults the Green Light

Ervebo shown to be highly effective in preventing infection in people exposed to the virus