Home 2019

Yearly Archives: 2019

Drug interactions between antiretroviral therapy and direct-acting antivirals pose a clinical challenge in patients with HIV/hepatitis C virus coinfection

Nurses Can Help Manage Drug Interactions in HIV/Hep C Treatment

Administration of simeprevir is more problematic with ART; sofosbuvir has fewest interactions with ART
Institutional imaging cores may help provide unbiased and reproducible measurements and enable a leaner workflow in assessing tumor measurements for patients participating in clinical trials

New Workflow Could Improve Imaging Assessment in Research

Use of a tumor response assessment core can avoid potential bias by medical oncologists in oncology trials
Autism spectrum disorder is markedly heritable

Severity of Autism Symptoms May Vary in Monozygotic Twins

Trait correlations for MZ twins differed according to the clinical range of severity for autistic symptoms
Among infants breastfed by mothers who are receiving drug therapy for epilepsy

Antiepileptic Drug Exposure Low in Breastfeeding Infants

Median percentage of infant-to-mother AED concentration ranged from 0.3 to 44.2 percent
A frailty scale that includes Eastern Cooperative Oncology Group performance status may predict outcomes for transplant-ineligible patients with newly diagnosed multiple myeloma

Frailty Score May Predict Outcomes in Multiple Myeloma

Frailty score based on age, Charlson Comorbidity Index, ECOS PS predicts outcomes in FIRST trial
Individuals with objectively-defined subtle cognitive difficulties have faster amyloid accumulation and faster entorhinal cortical thinning compared with cognitively normal individuals

Subtle Cognitive Difficulties May Predict Amyloidosis

Individuals with objectively-defined SCD have faster amyloid accumulation, entorhinal cortical thinning
A machine learning system can generate clinically valid alerts for medication errors that might be missed with existing clinical decision support systems

Machine Learning System Makes More Alerts for Med Errors

68.2 percent of MedAware alerts would not have been generated with clinical decision support system
For adults with posttraumatic stress disorder

Neither Psychotherapy Nor Medications Favored for PTSD

Evidence insufficient to determine whether psychotherapy, medications are more effective
Atopic dermatitis is associated with vitiligo

Study Shows Link Between Atopic Dermatitis and Vitiligo

Subgroup analyses show significant associations between adult, childhood AD and vitiligo
Resting-state functional magnetic resonance imaging measures may be able to predict symptoms of attention-deficit/hyperactivity disorder or major depressive disorder in children

fMRI Measures May Predict Psychiatric Symptoms in Children

Less positive coupling between sgACC, DLPFC at age 7 linked to increase in internalizing behaviors at 11