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Nintedanib plus sildenafil does not provide benefit over nintedanib alone for patients with idiopathic pulmonary fibrosis and diffusion capacity of the lungs for carbon monoxide of 35 percent or less of the predicted value

Nintedanib Plus Sildenafil No Better Than Nintedanib in IPF

No benefit with sildenafil in idiopathic pulmonary fibrosis with severe impairment in gas exchange
Once low rheumatoid arthritis disease activity is achieved with tocilizumab plus methotrexate

Combo Therapy Not Needed If Low RA Disease Activity Achieved

Dropping methotrexate, continuing tocilizumab does not lead to worsening of disease activity
Components of pharmacist-led discharge counseling vary widely

Components of Pharmacist-Led Discharge Counseling Vary

Use of a dosage schedule, teach-back technique more commonly reported in studies outside the U.S.
High-risk anticholinergic prescriptions are listed for 6.2 percent of visits of older adults

High-Risk Anticholinergics Prescribed to 6 Percent of Elderly

Correlates of receiving prescription include female sex, specific physician specialty, geographic region
On average

Hospitals Charge 479 Percent of Cost of Drugs on Average

Seventeen percent of hospitals charge 700 percent of cost; 8 percent have markup over 1,000 percent
Allopurinol dose escalation is not associated with reductions in mortality risk among patients with gout

Allopurinol Dose Escalation for Gout Doesn’t Improve Mortality

Linked to small increase in mortality; at 2 years, 31 percent of dose escalators achieved serum urate goal
Fourteen percent of older adults hospitalized with non-cardiac conditions are discharged with intensified antihypertensive treatment

HTN Tx Intensification Common Upon Discharge in U.S. Vets

Fourteen percent of older adults admitted to hospital for non-cardiac conditions had intensification of tx
Almost 20 percent of children and adolescents used prescription medications in 2013 to 2014

20% of Children, Adolescents Use Prescription Medications

8.2 percent of concurrent users of prescription meds at risk for potentially major drug-drug interactions
Quarterly canakinumab administration is associated with significantly reduced risk for gout attacks without any change in serum uric acid levels

Quarterly Canakinumab Reduces Risk for Gout Attacks

Doesn't affect serum uric acid levels over time, but targets interleukin-1β
Prices for drugs under shortage increase more than twice as quickly as expected in the absence of a shortage

Drug Prices Increase More Than Expected After Shortages

Expected price increase 20 percent for all drugs after shortage versus 9 percent in absence of shortage