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The rate of off-label ordering of systemic drugs has increased for children

Off-Label Ordering of Systemic Drugs Up for Children

Over time, off-label orders have increased for antihistamines, several psychotropics
Teens who misuse prescription or illicit opioids might benefit from the opioid treatment medications methadone

Pharmaceutical Treatments for Opioid Abuse May Benefit Teens

However, evidence is limited on efficacy, safety of medications for opioid use disorder in teens
Acetaminophen use in mid-to-late pregnancy may have an adverse effect on early childhood neurocognitive outcome

Acetaminophen in Pregnancy May Affect Childhood Behavior

12 variables, mainly features of hyperactive or attentive behavior, tied to acetaminophen use
For adults with noninfectious uveitis

Mycophenolate Mofetil Does Not Top MTX in Noninfectious Uveitis

Control of inflammation not superior with mycophenolate mofetil versus methotrexate
For patients with heart failure and reduced ejection fraction

Sacubitril-Valsartan Does Not Impact Aortic Stiffness in HFrEF

But it is linked to improvements in cardiac structure, function including decreases in LVESVI, LVEDVI
Ticagrelor plus aspirin compared with placebo plus aspirin is associated with a lower incidence of ischemic cardiovascular events but a higher incidence of major bleeding among patients with stable coronary artery disease and type 2 diabetes

Benefit, Harm Seen for Ticagrelor Plus Aspirin in Stable CAD With T2DM

Incidence of ischemic cardiovascular events lower but major bleeding increased versus placebo plus aspirin
Current evidence does not support routine use of haloperidol or second-generation antipsychotics for prevention or treatment of delirium in hospitalized adults

Evidence Says Antipsychotics Do Not Prevent Delirium in Adults

Evidence also refutes routine use of haloperidol, second-generation antipsychotics for tx of delirium
The U.S. Preventive Services Task Force recommends that clinicians offer risk-reducing medications to women at increased breast cancer risk. These recommendations form the basis of a final recommendation statement published in the Sept. 3 issue of the Journal of the American Medical Association.

USPSTF Advises Meds to Reduce Risk for Primary Breast Cancer

Offer risk-reducing meds to women at higher risk for breast cancer, low risk for adverse medication effects
Netarsudil ophthalmic solution (0.02 percent; once daily) significantly reduced mean intraocular pressure among patients with open-angle glaucoma or ocular hypertension

Netarsudil Lowers IOP in Glaucoma, Ocular Hypertension

ROCKET-4 study shows once-daily netarsudil noninferior to twice-daily timolol
Use of dipeptidyl peptidase-4 inhibitors is associated with increased risks for pancreatitis and pancreatic cancer in patients with newly diagnosed type 2 diabetes

Dipeptidyl Peptidase-4 Inhibitors May Up Pancreatic Disease Risk

Risks for pancreatitis, pancreatic cancer higher in Korean patients with newly diagnosed T2DM