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Tag: Liver Disease: Misc.

Nonalcoholic steatohepatitis associated changes in liver function affect kidney transporter expression and metformin pharmacokinetics

NASH-Linked Changes Impact Metformin Pharmacokinetics

Mice study shows alteration in kidney transporter expression, altered metformin pharmacokinetics
For patients with acute liver failure

Live Donor Transplant Good Option in Acute Liver Failure

No difference in incidence of post-op complications versus deceased donor liver transplant
Cholbam (cholic acid) capsules have been approved by the U.S. Food and Drug Administration to treat adults and children with bile acid synthesis disorders and peroxisomal disorders

FDA Approves Cholbam for Rare Bile Acid Synthesis Disorders

Drug is approved as an oral treatment for children aged 3 weeks and older, and adults
For patients with hepatitis C virus

Cost-Effectiveness of Immediate HCV Rx in Early Disease Analyzed

Rx tied to substantial costs that may compel clinicians, patients to consider delaying treatment
A novel oral substrate reduction therapy

Eliglustat Safely Reverses Manifestations of Gaucher’s

Significant improvement in spleen volume for untreated adults with type 1 disease
For liver transplantation recipients with model for end-stage liver disease scores above 11

Decreasing Serum Sodium Ups Liver Transplant Survival

Survival benefit for patients with MELD >11; no benefit seen for patients with MELD scores of ≤11
Dipeptidyl peptidase-4 inhibition may attenuate hepatic steatosis and insulin resistance induced by the Western diet through hepatic lipid remodeling and modulation of hepatic mitochondrial function

How Does DPP-4 Inhibition Affect Liver Function?

Mechanisms may involve hepatic lipid remodeling and modulation of hepatic mitochondrial function
Many hepatitis C patients get "lost" in the U.S. health care system

Many Patients With HCV ‘Lost’ in U.S. Health Care System

Patients lost at each stage, from screening to disease confirmation to care and treatment