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For adult patients with de novo acute myeloid leukemia

Genomic Approach Could Aid Risk Stratification in Adults With AML

Persistent leukemia-linked mutations in remission samples tied to increased relapse, worse survival
For some

BRAF V600 Is Targetable in Some Nonmelanoma Cancers

Vemurafenib active in NSCLC, Erdheim-Chester disease, Langerhans'-cell histiocytosis
A single nucleotide variant in the FTO obesity locus disrupts a conserved motif

Role of SNP Variant in FTO Explored in Obesity

Study identifies mechanistic basis for the strongest genetic association with obesity
Most lice populations have point mutations that are linked to pyrethroid resistance

Most Lice Populations Show Resistance to Pyrethroids

104 of 109 samples from 30 states were 100 percent resistant in three point mutations
Deleterious mutations in RAD51C and RAD51D genes are associated with increased risk of epithelial ovarian cancer

RAD51 Mutations Confer Moderate Risk of Ovarian Cancer

RAD51C and RAD51D deleterious mutations linked to increased risk of epithelial ovarian cancer
The risk of acute graft-versus-host disease in hematopoietic stem cell transplantation with HLA-DPB1 mismatching is influenced by the HLA-DPB1 rs9277534 expression marker

Genetic Variant Ups Risk of Graft-Versus-Host Disease in HSCT

Rejection seen with high-expression allele recipient, low-expression allele donor in HLA-DPB1 mismatches
Multigene testing for hereditary breast and/or ovarian cancer identifies more mutations that are likely to change clinical management

Multigene Test IDs More at Risk for Hereditary Breast/Ovarian CA

Testing for mutations other than BRCA1/2 in HBOC may change clinical management for women, families
Individuals with long telomeres are at increased risk for lung adenocarcinoma but not other types of cancer

Telomere Length May Help Predict Lung Cancer Risk

No significant association seen between telomere length and other types of cancer
Researchers have developed a genetic test to quickly detect enterovirus D68. The researchers published details of the test's techniques online recently in the Journal of Clinical Microbiology.

New Gene Test Speeds Diagnosis of Enterovirus D68

Virus sickened more than 1,000 U.S. children last year, 14 deaths reported
An individual's genetic makeup may determine whether an HIV vaccine will work

Genes May Be Key to a Better HIV Vaccine

Findings challenge one-shot-fits-all approach, could guide development of future vaccines