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Tag: Cancer: Colon

The U.S. Preventive Services Task Force (USPSTF) concludes that there is a substantial net benefit for screening adults age 50 to 75 years for colorectal cancer and moderate net benefit for adults ages 45 to 49 years. These findings form the basis of a draft recommendation statement published online Oct. 27 by the USPSTF.

USPSTF Issues Draft Recommendation for CRC Screening

Benefit substantial for adults aged 50 to 75 years; benefit moderate for adults aged 45 to 49 years
Decreased colorectal cancer incidence is seen in association with use of aspirin

Review IDs Dietary Factors Linked to Lower CRC Incidence

Incidence up with frequent alcohol or meat consumption; no evidence of protective effect found for tea, coffee
Many patients with biopsy-confirmed advanced colorectal polyps are unaware of their need for repeat colonoscopy as well as the proper surveillance interval

High-Risk Patients Not Aware of Needed Colonoscopy Intervals

Findings among patients with biopsy-confirmed advanced colorectal polyps
For patients with familial adenomatous polyposis

Eflornithine + Sulindac Shows No Benefit in Adenomatous Polyposis

Incidence of disease progression not significantly lower with combo versus either drug alone
The use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers is associated with lower risk of colorectal cancer risk that develops within three years after index colonoscopy

CRC Risk Down With ACEi, Angiotensin Receptor Blocker Use

5 percent reduction in adjusted hazard ratio risk with each single year increase in drug use
For patients with Lynch syndrome

Aspirin Tied to Lasting Reduction in CRC Risk in Lynch Syndrome

Reduced risk for colorectal cancer seen in intention-to-treat and per-protocol analyses
For patients with colorectal cancer and diabetes

Adherence to Diabetes Meds May Cut Mortality in Colorectal Cancer

Patients with colorectal cancer and diabetes have better survival with adherence to diabetes meds
Colorectal cancer incidence and mortality are reduced for a period of 17.4 years following a single negative screening colonoscopy

Lasting Drop Seen in CRC Incidence, Death After Negative Colonoscopy

Reductions only seen for 10.1 to 17.4 years of follow-up after high-quality colonoscopy
Regular aspirin use is associated with a lower risk for colorectal and other digestive tract cancers

Regular Aspirin Use Tied to Lower Risk for Digestive Tract Cancers

Favorable effect increases with longer duration of use, and, for colorectal cancer, with increasing dose
About one in four cases of colorectal cancer in patients aged 40 to 49 years meet family history-based criteria for early screening

Family History-Based Early Screen Could ID More Young-Onset CRC

Almost all who met criteria for early screening could have initiated screening before age of diagnosis