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Tag: Cancer: Breast

Tamoxifen at a dose of 5 mg/day is associated with a reduced risk for recurrence for women with hormone-sensitive breast intraepithelial neoplasia

SABCS: Low-Dose Tamoxifen Cuts Risk for Breast Dz

More second primary cancers and more frequent menopausal symptoms seen in tamoxifen vs. placebo arm
Black women with breast cancer have worse clinical outcomes even when 21-gene recurrence scores are similar

SABCS: Breast Cancer Outcomes Worse for Blacks Despite Similar Gene RS

Black race was associated with worse clinical outcomes among entire population
Subsequent imaging is required for 10 to 15.5 percent of women who undergo mastectomy

Imaging, Biopsy Often Still Needed After Mastectomy

10 to 15.5 percent of women undergo subsequent imaging; 6 to 8 percent undergo biopsy
For patients with residual invasive disease after neoadjuvant chemotherapy including a taxane and trastuzumab

SABCS: T-DM1 Cuts Recurrent Invasive HER2+ Breast CA Risk

Risk reduced with trastuzumab emtansine in those with residual invasive dz at sx after neoadjuvant chemo
Delaying initiation of adjuvant chemotherapy in triple-negative breast cancer patients more than 30 days after surgery is associated with a decrease in survival

SABCS: Delaying Chemo Lowers Survival in Triple-Neg Breast CA

Findings show delaying chemo over 30 days postsurgery lowers triple-negative breast cancer survival
Though common breast cancer variants indicate increased breast cancer risk

Rare Variants Associated With Interval Breast Cancers

The presence of these variants is also linked to increased risk for death
Women aged 75 years and older can still benefit from routine mammography

RSNA: Mammography Has Value in Women Age 75 or Older

Cancer detection rate is 8.4/1,000 exams in older women; 98 percent of cancers surgically excised
For patients with breast cancer

Breast Cancer Recurrence Rate Not Up With Autologous Fat Transfer

Reconstruction with autologous fat transfer seems not to increase rate of locoregional recurrence
For premenopausal women with stage I to IIIA estrogen receptor-negative

Improved Long-Term Pregnancy Outcomes for Goserelin + Chemo

Findings seen in premenopausal women with stage I to IIIA hormone receptor-negative breast cancer
A polygenic risk score can identify subsequent breast cancer risk among childhood survivors of cancer

Genetic Risk Score IDs Breast CA Risk in Female Child CA Survivors

Survivors in highest quintile of polygenic risk score have increased relative rate of breast cancer