Tag: Alzheimer’s
Alzheimer, Parkinson Disease Share Protective Association at HLA Locus
Protective HLA-DRB1*04 subtypes bind strongly to aggregation-prone tau PHF6 sequence when acetylated at K311
Panel of 48 CSF Proteins Complements Existing Alzheimer Biomarkers
CSF 48 panel plus existing biomarkers significantly improved diagnostic performance for outcomes studied
Routine Vaccines Can Cut Risk for Later Alzheimer Disease
Findings seen for tetanus and diphtheria, shingles, and pneumococcus vaccines
Eligibility Limited for Anti-β Amyloid mAbs in Seniors With MCI
Few older adults with MCI or mild dementia were eligible for lecanemab, aducanumab after applying clinical trial criteria
Racial/Ethnic Minorities Underrepresented in Alzheimer Neuroimaging Research
Sample diversity has improved recently, with proportion of Blacks increasing from 3.39 percent in 1994-2017 to 8.29 percent in 2018-2022
Finger Prick, Venous Blood Can ID Key Alzheimer Disease Biomarkers
Capillary and venous dry blood spot can identify glial fibrillary acidic protein, neurofilament light, phosphorylated tau
Excess Alzheimer, Related Dementia-Linked Mortality Increased During COVID-19
Large increase seen in mortality with ADRD as underlying, contributing cause of death in pandemic year 1
Solanezumab Does Not Slow Cognitive Decline in Preclinical Alzheimer Disease
Mean change in Preclinical Alzheimer Cognitive Composite score not significantly different at 240 weeks with solanezumab, placebo
Eastern, Southeastern U.S. Have Highest Prevalence of Alzheimer Disease
Counties with the highest prevalence were Miami-Dade County in Florida, Baltimore County in Maryland, and Bronx County in New York
Donanemab Slows Clinical Progression in Early Alzheimer Disease
Slows clinical progression at 76 weeks for those with low/medium tau and the combined low/medium and high tau pathology population
