Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for December 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
No Effect for BUP TAP Catheter on Chronic Pain After Breast Recon
FRIDAY, Dec. 30, 2016 (HealthDay News) — For patients undergoing autologous breast reconstruction, the incidence of chronic postsurgical pain (CPSP) does not differ for patients receiving transversus abdominis plane (TAP) catheters delivering bupivacaine or saline bolus, according to a study published online Dec. 20 in Pain Practice.
Full Text (subscription or payment may be required)
Burden of Anticholinergic Meds in Older Adults Must Be Considered
FRIDAY, Dec. 30, 2016 (HealthDay News) — Anticholinergic medications are frequently prescribed to older adults, but their negative impact should be considered, according to a review published online Dec. 23 in the Journal of Pharmacy Practice and Research.
Full Text (subscription or payment may be required)
Ledipasvir-Sofosbuvir Effective for Chronic HCV in Adolescents
FRIDAY, Dec. 30, 2016 (HealthDay News) — For adolescents with chronic hepatitis C virus (HCV) genotype 1 infection, ledipasvir-sofosbuvir is highly effective, according to a study published online Dec. 20 in Hepatology.
Full Text (subscription or payment may be required)
Lactobacillus Supplement Doesn’t Impact HbA1c in Type 2 Diabetes
FRIDAY, Dec. 30, 2016 (HealthDay News) — For patients with type 2 diabetes on insulin therapy, oral supplementation with Lactobacillus reuteri DSM 17938 does not affect glycated hemoglobin (HbA1c), according to a study published online Dec. 23 in Diabetes, Obesity and Metabolism.
Full Text (subscription or payment may be required)
Pharmacy-Based Sale of Chlamydia Test Kits Is Effective
FRIDAY, Dec. 30, 2016 (HealthDay News) — It is feasible to sell chlamydia test kits through pharmacies and use existing health infrastructure to follow up on results and manage clients, according to a pilot study published online Dec. 23 in the Journal of Pharmacy Practice and Research.
Full Text (subscription or payment may be required)
Ustekinumab Tolerated in Severe Atopic Dermatitis
THURSDAY, Dec. 29, 2016 (HealthDay News) — Ustekinumab is tolerated for treatment of atopic dermatitis (AD) in certain patients, according to a research letter published online Dec. 22 in the British Journal of Dermatology.
Full Text (subscription or payment may be required)
Selumetinib Active in Children With Neurofibromatosis Type 1
THURSDAY, Dec. 29, 2016 (HealthDay News) — The oral selective inhibitor of MAPK kinase 1 and 2, selumetinib, is active in children with neurofibromatosis type 1 and inoperable plexiform neurofibromas, according to a study published in the Dec. 29 issue of the New England Journal of Medicine.
Full Text (subscription or payment may be required)
Aflibercept Rescues Vision After Laser for Diabetic Macular Edema
THURSDAY, Dec. 29, 2016 (HealthDay News) — For eyes experiencing substantial visual loss after macular laser photocoagulation treatment for diabetic macular edema (DME), intravitreal aflibercept improves visual and anatomic outcomes, according to a study published online Dec. 22 in JAMA Ophthalmology.
Phase I Trial Shows Promise for Cimaglermin in Heart Failure
WEDNESDAY, Dec. 28, 2016 (HealthDay News) — The recombinant growth factor, cimaglermin alfa, may enhance cardiac function in left ventricular systolic dysfunction (LVSD), according to a study published in the Dec. 1 issue of JACC: Basic to Translational Science.
Fish-Oil Fatty Acids in Pregnancy Cut Wheeze, Asthma Risk in Child
WEDNESDAY, Dec. 28, 2016 (HealthDay News) — For women in the third trimester of pregnancy, supplementation with n-3 long-chain polyunsaturated fatty acids (LCPUFAs) is associated with a reduction in the risk of persistent wheeze and asthma in offspring, according to a study published in the Dec. 29 issue of the New England Journal of Medicine.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Optimal Timing ID’d for Flu Shot During Three-Week Chemo Cycle
WEDNESDAY, Dec. 28, 2016 (HealthDay News) — For adults with solid cancer undergoing three-week cytotoxic chemotherapy cycles, antibody responses are comparable for influenza vaccination on day one and 11, according to a study published online Dec. 20 in Cancer.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Ciprofloxacin Plus Fluocinolone More Effective for Peds AOMT
WEDNESDAY, Dec. 28, 2016 (HealthDay News) — For children with acute otitis media with tympanostomy tubes (AOMT), ciprofloxacin plus fluocinolone is more effective than ciprofloxacin or fluocinolone alone, according to a study published online Dec. 22 in JAMA Otolaryngology-Head & Neck Surgery.
Case Report: Ustekinumab for Crohn’s Continued in Pregnancy
WEDNESDAY, Dec. 28, 2016 (HealthDay News) — Good outcome has been reported in a pregnant woman who continued ustekinumab (UST) therapy for Crohn’s disease during pregnancy, according to a case report published online Dec. 22 in the Journal of Clinical Pharmacy and Therapeutics.
Full Text (subscription or payment may be required)
Bell’s Palsy Tied to Quadrivalent Meningococcal Vaccine
WEDNESDAY, Dec. 28, 2016 (HealthDay News) — Bell’s palsy is the only prespecified adverse event associated with the MenACWY-CRM quadrivalent meningococcal conjugate vaccine, according to a study published online Dec. 26 in Pediatrics.
Opicapone As Levodopa Adjunct Cuts Motor Fluctuations in PD
TUESDAY, Dec. 27, 2016 (HealthDay News) — For patients with Parkinson’s disease (PD) receiving levodopa therapy and experiencing end-of-dose motor fluctuations, treatment with 50-mg/day opicapone is associated with a reduction in mean daily off-time, according to a study published online Dec. 27 in JAMA Neurology.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Personal Health Care Spending Continues to Soar in the U.S.
TUESDAY, Dec. 27, 2016 (HealthDay News) — From 1996 to 2013 there were considerable increases in personal health care spending in the United States, with the highest amounts for diabetes, ischemic heart disease, and low back and neck pain, according to a study published in the Dec. 27 issue of the Journal of the American Medical Association.
Full Text
Editorial (subscription or payment may be required)
Most Postpartum Moms OK With Self-Administered Pain Meds
TUESDAY, Dec. 27, 2016 (HealthDay News) — There is high satisfaction for a postpartum self-administered medication (SAM) program on postpartum wards, according to a study published online Dec. 20 in the Journal of Evaluation in Clinical Practice.
Full Text (subscription or payment may be required)
Oxidative Stress Tied to Early-Onset Androgenetic Alopecia
TUESDAY, Dec. 27, 2016 (HealthDay News) — Younger patients with early-onset androgenetic alopecia (AGA) have increased oxidative stress, according to a study published online Dec. 16 in the Journal of Cosmetic Dermatology.
Full Text (subscription or payment may be required)
Rifaximin Effective for Repeat Treatment of IBS With Diarrhea
TUESDAY, Dec. 27, 2016 (HealthDay News) — Repeat treatment with the nonsystemic antibiotic rifaximin is effective in patients with relapsing symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D), according to a study published in the December issue of Gastroenterology.
Police Referral Without Arrest Lets Opioid Abusers Seek Help
TUESDAY, Dec. 27, 2016 (HealthDay News) — A direct referral program and use of an interim buprenorphine regimen can be beneficial for encouraging individuals with an opioid-use disorder to seek help, and for reducing drug-related risks, according to two research letters published online Dec. 21 in the New England Journal of Medicine.
Full Text – Schiff
Full Text – Sigmon
Recombinant Type-5 Vector-Based Ebola Vaccine Safe
TUESDAY, Dec. 27, 2016 (HealthDay News) — For healthy adults from Sierra Leon, the recombinant type-5 vector-based Ebola vaccine is safe and immunogenic, according to a study published online Dec. 21 in The Lancet.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Cognitive Therapy Alone Most Effective for Social Anxiety
FRIDAY, Dec. 23, 2016 (HealthDay News) — Cognitive therapy (CT) is more effective treatment for social anxiety disorder (SAD), compared to paroxetine alone or in combination with CT, according to a study published recently in Psychotherapy and Psychosomatics.
PPI Cuts Risk of Warfarin-Related Upper GI Bleeding
FRIDAY, Dec. 23, 2016 (HealthDay News) — For patients beginning warfarin therapy, proton pump inhibitor (PPI) co-therapy is associated with reduced risk of upper gastrointestinal bleeding, according to a study published in the December issue of Gastroenterology.
Impact of Complex Medication Regimen in Elderly Unclear
FRIDAY, Dec. 23, 2016 (HealthDay News) — The association between medication regimen complexity and either treatment nonadherence or hospitalization in elderly patients remains unclear, according to a review published online Dec. 19 in the Journal of the American Geriatrics Society.
Full Text (subscription or payment may be required)
Structured Rounding Tools Aid Multidisciplinary Rounds
FRIDAY, Dec. 23, 2016 (HealthDay News) — The use of structured rounding tools improves time allocation per patient and communication breakdowns during hand-offs in multidisciplinary rounds, according to a study published recently in JMIR Human Factors.
Shortened Abx Inferior for Acute Otitis Media in Children <2 Years
THURSDAY, Dec. 22, 2016 (HealthDay News) — Reduced-duration antimicrobial treatment is associated with less favorable outcomes among infants with acute otitis media, according to a study published in the Dec. 22 issue of the New England Journal of Medicine.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Ocrelizumab Targets Role of B Cells in Multiple Sclerosis
THURSDAY, Dec. 22, 2016 (HealthDay News) — Ocrelizumab, a new and fully humanized monoclonal anti-CD20 antibody that causes B-cell depletion, is associated with lower relapse rate and lower rates of progression among patients with relapsing or primary progressive multiple sclerosis, respectively, according to research published online Dec. 21 in the New England Journal of Medicine.
Abstract – Hauser
Full Text
Abstract – Montalban
Full Text
Editorial
Single-Dose LMWH Can Interfere With Algorithm for DVT Diagnosis
THURSDAY, Dec. 22, 2016 (HealthDay News) — A single dose of low-molecular-weight heparin (LMWH) given the previous day can reduce D-dimer and potentially risk non-identification of a deep vein thrombosis (DVT), according to a research letter published online Dec. 15 in the International Journal of Laboratory Hematology.
Full Text (subscription or payment may be required)
Risk of Uterine Fibroids Found to Be Lower in Women Using Statins
WEDNESDAY, Dec. 21, 2016 (HealthDay News) — The use of statins is associated with a lower risk of uterine fibroids and fibroid-related symptoms, according to a study published in the December issue of the American Journal of Obstetrics & Gynecology.
Full Text (subscription or payment may be required)
Serum Biomarker That Reflects Use, Dose of Metformin Identified
WEDNESDAY, Dec. 21, 2016 (HealthDay News) — The growth differentiation factor 15 (GDF15) is a novel biomarker for the use and dosing of metformin, according to a study published online Dec. 14 in Diabetes Care.
Full Text (subscription or payment may be required)
Mouthwash May Be Useful for Gonorrhea Control
WEDNESDAY, Dec. 21, 2016 (HealthDay News) — Listerine mouthwash may be potentially useful for gonorrhea control, according to a study published online Dec. 20 in Sexually Transmitted Infections.
Pritelivir Beats Valacyclovir for Genital HSV-2 Shedding
WEDNESDAY, Dec. 21, 2016 (HealthDay News) — The novel herpes simplex virus (HSV) helicase-primase inhibitor pritelivir is more effective than valacyclovir for reducing genital HSV-2 shedding, according to a study published in the Dec. 20 issue of the Journal of the American Medical Association.
Full Text (subscription or payment may be required)
2002 to 2014 Saw Increase in Marijuana Use in Women
TUESDAY, Dec. 20, 2016 (HealthDay News) — The prevalence of marijuana use increased among women from 2002 to 2014, and less than 10 percent of adult marijuana users report use for medical purposes, according to two research letters published online Dec. 19 in the Journal of the American Medical Association.
Full Text – Brown
Full Text – Compton
CDC: Fatal Drug Overdoses Up Significantly in the United States
TUESDAY, Dec. 20, 2016 (HealthDay News) — Drug overdose deaths increased 23 percent between 2010 and 2014, with 47,055 Americans dying in 2014, according to findings published in the Dec. 20 issue of the U.S. Centers for Disease Control and Prevention’s National Vital Statistics Reports.
Regular Aspirin Use Linked to Reduced Risk of Pancreatic CA
TUESDAY, Dec. 20, 2016 (HealthDay News) — Regular aspirin use is associated with reduced risk of pancreatic cancer in a Chinese cohort, according to a study published online Dec. 20 in Cancer Epidemiology, Biomarkers & Prevention.
Full Text (subscription or payment may be required)
Lowest Glucose Variability for Insulin + GLP-1 RA in T2DM
TUESDAY, Dec. 20, 2016 (HealthDay News) — For patients with type 2 diabetes, the lowest glucose variability (GV) and hypoglycemia is seen for patients using basal insulin + glucagon-like peptide 1 receptor agonist (GLP-1 RA) (BGLP), according to a study published online Dec. 2 in Diabetes Care.
Full Text (subscription or payment may be required)
Health Care Provider Burnout Negatively Affects Quality, Safety
TUESDAY, Dec. 20, 2016 (HealthDay News) — Health care provider burnout is negatively associated with quality and safety of health care, according to a meta-analysis published recently in the Journal of General Internal Medicine.
Full Text (subscription or payment may be required)
Daily Text Messaging Ups ART Adherence in Youth
TUESDAY, Dec. 20, 2016 (HealthDay News) — A two-way, personalized daily text messaging intervention can improve antiretroviral therapy (ART) adherence among HIV-positive adolescents and young adults, according to a study published in AIDS and Behavior.
Full Text (subscription or payment may be required)
FDA Grants Fast-Track Approval to Ovarian Cancer Drug
MONDAY, Dec. 19, 2016 (HealthDay News) — The drug Rubraca (rucaparib) has been granted accelerated approval by the U.S. Food and Drug Administration to treat advanced ovarian cancer.
DEA Announces Critical Changes in Registration Renewal Process
MONDAY, Dec. 19, 2016 (HealthDay News) — The Drug Enforcement Administration (DEA) has announced critical changes in its registration renewal process, according to a report published by the American Academy of Family Physicians.
Twitter Chatter About HPV Vaccine Mostly Positive
MONDAY, Dec. 19, 2016 (HealthDay News) — Twitter conversations regarding the human papillomavirus (HPV) vaccine tend to be positive, according to a study published online Dec. 5 in the Journal of Medical Internet Research.
Dysglycemia Affects Brain Structure, Cognition in Seniors
MONDAY, Dec. 19, 2016 (HealthDay News) — In older adults, dysglycemia is associated with brain structure and cognition, according to a study published online Dec. 5 in the Journal of the American Geriatrics Society.
Full Text (subscription or payment may be required)
Long-Term DPP4-Inhibitor Use Not Tied to Fracture Risk in T2DM
MONDAY, Dec. 19, 2016 (HealthDay News) — For patients with type 2 diabetes mellitus (T2DM), long-term use of dipeptidyl peptidase-4 inhibitors (DPP4-Is) is not associated with fracture risk, according to a study published online Dec. 10 in Diabetes, Obesity and Metabolism.
Full Text (subscription or payment may be required)
Adjuvant Chemo Plus CRT Best in Nasopharyngeal Carcinoma
MONDAY, Dec. 19, 2016 (HealthDay News) — For nonmetastatic nasopharyngeal carcinoma, the addition of adjuvant chemotherapy (AC) to chemoradiotherapy (CRT) is associated with the highest survival benefit, according to research published online Dec. 5 in the Journal of Clinical Oncology.
Imiquimod Has Sustained Benefit for Basal Cell Carcinoma
FRIDAY, Dec. 16, 2016 (HealthDay News) — For superficial or nodular basal cell carcinoma at low-risk sites, imiquimod has lower treatment success rates than surgery but the benefit is sustained at five years, according to a study published online Dec. 5 in the Journal of Investigative Dermatology.
Full Text (subscription or payment may be required)
Opioid-Related Hospitalizations Up Sharply in the United States
FRIDAY, Dec. 16, 2016 (HealthDay News) — Hospital admissions related to overdoses from heroin and other opioids rose 64 percent in the United States between 2005 and 2014, according to a report from the U.S. Agency for Healthcare Research and Quality (AHRQ).
Pioglitazone Improves Whole-Body Aerobic Capacity in MetS
FRIDAY, Dec. 16, 2016 (HealthDay News) — For adults with metabolic syndrome (MetS), pioglitazone treatment improves whole-body aerobic capacity, according to a study published online Dec. 12 in the Journal of Diabetes Investigation.
Full Text (subscription or payment may be required)
‘Zombie’ Outbreak in NYC Caused by Synthetic Cannabinoid
THURSDAY, Dec. 15, 2016 (HealthDay News) — Synthetic cannabis that triggered a “zombie” outbreak in a New York City neighborhood last summer was significantly more potent than real cannabis, according to a study published online Dec. 14 in the New England Journal of Medicine.
SIOP Scale Best for Detecting Ototoxicity With Cisplatin Tx
THURSDAY, Dec. 15, 2016 (HealthDay News) — The Society for Industrial and Organizational Psychology Ototoxicity Scale (SIOP) seems to be best for classifying ototoxicity in cisplatin-treated pediatric patients, according to a study published online Dec. 12 in the Journal of Clinical Oncology.
Full Text (subscription or payment may be required)
AARP: Medication Costs for Seniors Continue to Soar
WEDNESDAY, Dec. 14, 2016 (HealthDay News) — The prices of brand-name drugs used by many older Americans rose nearly 130 times faster than inflation last year, according to a new report from the AARP Public Policy Institute.
Triple-Negative Breast Cancer Subtype Chemosensitive
WEDNESDAY, Dec. 14, 2016 (HealthDay News) — For patients with triple-negative breast cancer (TNBC), a BRCA-deficiency (BRCA-D) subtype is chemosensitive, according to a study published online Dec. 13 in PLOS Medicine.
Stroke, A-Fib Recurrence Low at One Year After AF Ablation
WEDNESDAY, Dec. 14, 2016 (HealthDay News) — Stroke and atrial fibrillation (AF) recurrence are low one year after AF ablation, according to a study published online Dec. 9 in the Journal of Cardiovascular Electrophysiology.
Full Text (subscription or payment may be required)
Outcomes-Based Pricing Suggested for New, Costly Drugs
WEDNESDAY, Dec. 14, 2016 (HealthDay News) — Outcomes-based pricing for novel and expensive biopharmaceuticals is supported in an Ideas and Opinions piece published online Dec. 13 in the Annals of Internal Medicine.
Full Text (subscription or payment may be required)
Data-Driven Algorithm Yields Notable Improvements in HbA1c
WEDNESDAY, Dec. 14, 2016 (HealthDay News) — A data-driven algorithm for personalized diabetes care can yield substantial improvements in hemoglobin A1c (HbA1c), according to a study published online Dec. 5 in Diabetes Care.
Full Text (subscription or payment may be required)
Sliding Scale Insulin Order Sheet Cuts Medication Errors
WEDNESDAY, Dec. 14, 2016 (HealthDay News) — A standardized sliding scale insulin (SSI) order sheet can reduce the incidence of SSI-related medication errors, according to a study published online Dec. 7 in the Journal of Evaluation in Clinical Practice.
Full Text (subscription or payment may be required)
Cetuximab + Chemoradiation Can Cure HIV-Associated Anal Cancer
WEDNESDAY, Dec. 14, 2016 (HealthDay News) — Definitive chemoradiation (CRT) can potentially cure HIV-associated squamous cell carcinoma of the anal canal (SCCAC), with the addition of cetuximab resulting in less locoregional failure (LRF), according to a study published online Dec. 12 in the Journal of Clinical Oncology.
Full Text (subscription or payment may be required)
Atezolizumab Effective in Late-Stage Non-Small-Cell Lung Cancer
TUESDAY, Dec. 13, 2016 (HealthDay News) — The immunotherapy atezolizumab extends the survival of previously treated non-small-cell lung cancer patients for several months and causes fewer side effects than docetaxel, according to a study published online Dec. 12 in The Lancet.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
β-Blockers May Not Be Appropriate for Dementia Patients
TUESDAY, Dec. 13, 2016 (HealthDay News) — β-blockers may not be the medicine of choice for nursing home residents with dementia, according to a study published online Dec. 12 in JAMA Internal Medicine.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Neonatal Abstinence Syndrome Up in Rural-Born Infants
TUESDAY, Dec. 13, 2016 (HealthDay News) — Rural U.S. communities are seeing a sharp increase in infants with neonatal abstinence syndrome (NAS), according to a research letter published online Dec. 12 in JAMA Pediatrics.
Primary Care Physician Volume Linked to Quality of Diabetes Care
TUESDAY, Dec. 13, 2016 (HealthDay News) — Primary care physician volume is associated with quality of diabetes care, with lower quality for higher overall volume and higher quality for higher diabetes-specific volume, according to a study published online Dec. 13 in the Annals of Internal Medicine.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
OSA Is Risk Factor for Recurrent Pulmonary Embolism
TUESDAY, Dec. 13, 2016 (HealthDay News) — For patients who stop oral anticoagulation (OAC) for a first episode of pulmonary embolism (PE), obstructive sleep apnea (OSA) is a risk factor for PE recurrence and restarting OAC for a new thromboembolic event, according to a study published in the December issue of CHEST.
Full Text (subscription or payment may be required)
Universal Group B Streptococci Screening Not Cost-Effective
TUESDAY, Dec. 13, 2016 (HealthDay News) — For women with a singleton pregnancy planning a repeat cesarean delivery, universal group B streptococci (GBS) screening is not cost-effective, according to a study published in the January issue of Obstetrics & Gynecology.
Full Text (subscription or payment may be required)
CDC: U.S. Flu Vaccination Rates Low So Far This Season
MONDAY, Dec. 12, 2016 (HealthDay News) — Only about two out of five Americans had gotten this season’s flu vaccination as of early November, the U.S. Centers for Disease Control and Prevention reports.
Rate of Psychiatric Drug Use About 16 Percent in U.S. Adults
MONDAY, Dec. 12, 2016 (HealthDay News) — One in six U.S. adults take a psychiatric medication to treat conditions such as depression, anxiety, and insomnia, according to a study published online Dec. 12 in JAMA Internal Medicine.
Effect of Statins on Alzheimer’s May Depend on Gender, Race
MONDAY, Dec. 12, 2016 (HealthDay News) — Effectiveness of statin use in Alzheimer’s prevention may depend on the specific statin, and the gender and race or ethnicity of the patient, according to a study published online Dec. 12 in JAMA Neurology.
Duration of Estrogen Rx May Be Important Factor in Renal Health
MONDAY, Dec. 12, 2016 (HealthDay News) — For midlife ovariectomized Long Evans rats, long-term estradiol (E2) treatment exerts detrimental effects on kidney health, despite lowering blood pressure, while short-term E2 lowers blood pressure and reduces renal damage, according to an experimental study published online Nov. 9 in American Journal of Physiology-Renal Physiology.
Full Text (subscription or payment may be required)
CDC Finds Vaccination Coverage Varies for Adults With Diabetes
MONDAY, Dec. 12, 2016 (HealthDay News) — Among adults with diagnosed diabetes, vaccination coverage varies, with influenza vaccination more prevalent than pneumococcal or hepatitis B vaccination, according to a December data brief published by the U.S. Centers for Disease Control and Prevention’s National Center for Health Statistics (NCHS).
Cytotoxic T-Cells Can Induce Metastatic CRC Regression
FRIDAY, Dec. 9, 2016 (HealthDay News) — Administration of cytotoxic T-cells targeting mutant KRAS G12D can induce tumor regression in metastatic colorectal cancer, according to a case report published in the Dec. 8 issue of the New England Journal of Medicine.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Naloxone Price Hikes Could Affect Rates of Opioid-Related Deaths
THURSDAY, Dec. 8, 2016 (HealthDay News) — Escalating prices of the drug naloxone may threaten efforts to reduce opioid-related deaths across America, according to a perspective piece published in the Dec. 8 issue of the New England Journal of Medicine.
Personalized Vaccine Effective Against Acute Myeloid Leukemia
THURSDAY, Dec. 8, 2016 (HealthDay News) — A vaccine made from patient-derived acute myeloid leukemia cells and dendritic cells can dramatically increase the chance of long-term survival against acute myeloid leukemia, according to research published in the Dec. 7 issue of Science Translational Medicine.
Full Text (subscription or payment may be required)
Nusinersen Shows Promise in Spinal Muscular Atrophy
THURSDAY, Dec. 8, 2016 (HealthDay News) — An experimental drug for infants with spinal muscular atrophy type 1 appears to be effective, according to research published online Dec. 5 in The Lancet.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Timely Epinephrine Increases Cardiac Arrest Survival
THURSDAY, Dec. 8, 2016 (HealthDay News) — Cardiac arrest patients who receive epinephrine within five minutes are more likely to survive than those who don’t receive the drug within that time frame, according to findings published online Dec. 1 in Circulation.
Full Text (subscription or payment may be required)
Sleep Duration, Efficiency Linked to Inpatient Hyperglycemia
THURSDAY, Dec. 8, 2016 (HealthDay News) — For hospitalized patients, additional sleep and increased sleep efficiency correlate with lower odds of hyperglycemia and impaired fasting glucose, according to research published online Nov. 30 in Diabetes Care.
Full Text (subscription or payment may be required)
Titanium Exposure Tied to Yellow Nail Syndrome in Pediatric Patient
THURSDAY, Dec. 8, 2016 (HealthDay News) — In a case report published online Dec. 7 in Pediatrics, yellow nail syndrome (YNS) is described in a 9-year-old girl who had titanium detected in her nail clippings.
Full Text (subscription or payment may be required)
Cannabis Use Up in Americans Aged 50 and Up
WEDNESDAY, Dec. 7, 2016 (HealthDay News) — More older Americans are using cannabis, according to a study published online Dec. 5 in Addiction.
Full Text (subscription or payment may be required)
Readings Taken in Clinic May Underestimate Ambulatory BP
WEDNESDAY, Dec. 7, 2016 (HealthDay News) — Ambulatory blood pressure may be a better indicator of health risks than clinic blood pressure, according to a new report published online Dec. 6 in Circulation.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Low Thromboembolism Risk for Contraceptive Use in Diabetes
TUESDAY, Dec. 6, 2016 (HealthDay News) — For women with diabetes who are using hormonal contraception, the absolute risk of thromboembolism is low, with the lowest rates seen with use of intrauterine and subdermal contraceptives, according to a study published online Nov. 29 in Diabetes Care.
Full Text (subscription or payment may be required)
Potentially Unsafe Med Scripts Up for Dual Users With Dementia
TUESDAY, Dec. 6, 2016 (HealthDay News) — For veterans with dementia, Veterans Affairs (VA)-Medicare Part D (dual-system) users have increased rates of potentially unsafe medication (PUM) prescribing, according to a study published online Dec. 6 in the Annals of Internal Medicine.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Thromboprophylaxis Not Effective After Knee Arthroplasty, Casting
MONDAY, Dec. 5, 2016 (HealthDay News) — The use of thromboprophylaxis seems not to prevent venous thromboembolism after knee arthroplasty or casting of the lower leg, according to a study published online Dec. 3 in The New England Journal of Medicine.
Biosimilar Promising for ERBB2+ Breast Cancer Treatment
MONDAY, Dec. 5, 2016 (HealthDay News) — A proposed biosimilar is comparable to trastuzumab for women with ERBB2-positive metastatic breast cancer, according to a study published online Dec. 1 in the Journal of the American Medical Association.
Full Text
Editorial 1
Editorial 2
Announcement Training Ups HPV Vaccination for Adolescents
MONDAY, Dec. 5, 2016 (HealthDay News) — Training providers to use announcements can increase human papillomavirus (HPV) vaccination coverage in young adolescents, according to a study published online Dec. 5 in Pediatrics.
Multimodal Breast Cancer Tx May Up Cytokines, Comorbidities
MONDAY, Dec. 5, 2016 (HealthDay News) — Breast cancer survivors who undergo multimodal treatment have higher cytokines and comorbidities than controls without cancer, according to a study published online Nov. 28 in the Journal of Clinical Oncology.
Dabigatran May Be Better Than Warfarin After Bleeding Episode
FRIDAY, Dec. 2, 2016 (HealthDay News) — Dabigatran is less likely than warfarin to cause recurrent bleeding in atrial fibrillation patients who have experienced a major bleeding event, according to a study published online Dec. 1 in Stroke.
Full Text (subscription or payment may be required)
Incidence of Hospitalization for Hypoglycemia Decreasing
FRIDAY, Dec. 2, 2016 (HealthDay News) — For patients with type 1 diabetes, the incidence of hospitalization for hypoglycemia (HH) decreased over time in Denmark, with an 8.4 percent annual decrease, according to a study published online Nov. 29 in Diabetes Care.
Full Text (subscription or payment may be required)
Meds Don’t Cut Trastuzumab-Tied Left Ventricular Remodeling
FRIDAY, Dec. 2, 2016 (HealthDay News) — For patients with human epidermal growth factor receptor 2-overexpressing (HER2-positive) early breast cancer, perindopril and bisoprolol do not prevent trastuzumab-mediated left ventricular remodeling, according to a study published online Nov. 28 in the Journal of Clinical Oncology.
Psilocybin Can Pull Cancer Patients Quickly Out of Despair
THURSDAY, Dec. 1, 2016 (HealthDay News) — A single dose of psilocybin can quickly lifts the spirits of cancer patients, and the effect can last as long as six months, according to two studies published online Dec. 1 in the Journal of Psychopharmacology.
Full Text – Griffiths
Full Text – Ross
Editorial
More HIV Patients Exhibiting Multidrug Resistance
THURSDAY, Dec. 1, 2016 (HealthDay News) — A significant number of patients with HIV have strains of the virus that are resistant to both older and newer drugs, according to research published online Nov. 30 in The Lancet Infectious Diseases.
Increased VTE Risk for Men Starting Testosterone Therapy
THURSDAY, Dec. 1, 2016 (HealthDay News) — Starting testosterone treatment is associated with an increased risk of venous thromboembolism (VTE), peaking within six months and declining thereafter, according to a study published online Nov. 30 in The BMJ.
CDC: Fewer U.S. Families Struggling to Pay Medical Bills
THURSDAY, Dec. 1, 2016 (HealthDay News) — The number of people in families having problems paying medical bills fell by nearly 13 million from 2011 through the first six months of 2016, according to a report published by the U.S. Centers for Disease Control and Prevention’s National Center for Health Statistics (NCHS).
Dapivirine Vaginal Ring Can Help Prevent HIV-1 Infection
THURSDAY, Dec. 1, 2016 (HealthDay News) — Use of a vaginal ring containing dapivirine is efficacious for prevention of HIV-1 infection, according to a study published in the Dec. 1 issue of the New England Journal of Medicine.
ABT-494 Effective for Patients With Rheumatoid Arthritis
THURSDAY, Dec. 1, 2016 (HealthDay News) — A novel selective JAK-1 inhibitor, ABT-494, is effective for rheumatoid arthritis (RA) patients with inadequate response to methotrexate (MTX) or to at least one anti-tumor necrosis factor (anti-TNF) agent, according to two studies published online Nov. 28 in Arthritis & Rheumatology.
Full Text – Genovese
Full Text – Kremer
Copyright © 2017 ScoutNews, LLC. All rights reserved.
