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Patients with melanoma treated with a combination of ipilimumab and nivolumab may be at risk for a potentially fatal T-cell-driven drug reaction

Myocarditis ID’d With Ipilimumab + Nivolumab in Melanoma

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Case report describes two patients who developed fatal T-cell-driven drug reaction
Healthy participants receiving the orally administered reversible fatty acid amide hydrolase inhibitor

Severe Neurologic Disorder With Administration of BIA 10-2474

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Phase 1 study involving healthy volunteers results in severe neurologic disorder, with one brain death
Ambulatory

Ambulatory IV Diuretics Cut Costs in Decompensated Heart Failure

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Ambulatory high-dose intravenous diuretic therapy cost saving versus hospitalization for diuretic tx
Pharmacogenetic analysis can help optimize clomipramine doses in patients who do not respond to standard-dose treatment

Pharmacogenetic Analyses Can Optimize Clomipramine Dosing

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Case report of woman with depressive episode who did not respond to standard dose of clomipramine
Three injections of a therapeutic vaccine may control herpes simplex virus 2 as effectively as daily pills for at least a year

ISDA: Vaccine Might Help Prevent HSV-2 Transmission

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Three-dose regimen seems as effective as daily pills, but more research needed

Infectious Diseases Society of America, Oct. 26-30

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The Infectious Diseases Society of America Annual Meeting (IDWeek 2016) The annual meeting of the Infectious Diseases Society of America was held from...
Transient addition of topical corticosteroids to topical retinoids is not associated with meeting the primary end points of improvement in acne severity and mitigation of medication-induced irritation

Transient Topical Corticosteroids of Limited Use in Acne

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Doesn't meet primary end points of improved acne severity, mitigation of retinoid-induced irritation
For ectopic pregnancy

Outcomes Similar for Rx Dosing Protocols in Ectopic Pregnancy

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Similar initial hCG levels with single-, double-dose protocols; more rapid decline with single-dose
The American Society of Clinical Oncology Clinical Practice Guideline on the integration of palliative care into standard oncology care has been updated. The update was published online Oct. 28 in the Journal of Clinical Oncology.

ASCO Updates Guidelines on Integration of Palliative Care

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Those with advanced cancer should receive dedicated palliative care services early in disease course
Community pharmacists are well suited to provide clinical preventive services

Community Pharmacists Play Role in Providing Preventive Care

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Report highlights role in folic acid education, tobacco use cessation, screening for osteoporosis, HIV