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Tag: Genetics

Radiation Therapy Can Promote Amphiregulin, Which Increases Growth of Metastases

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Patients whose tumors expressed increased amphiregulin had shorter progression-free and overall survival

AAP Offers Guidance for Genetic Evaluation of Neurodevelopmental Disorders

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Three-tiered agnostic approach is proposed based on diagnostic yield and practical considerations

BRCA Mutations Linked to Breast Implant Anaplastic Large Cell Lymphoma

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Age-adjusted rate of developing BIA-ALCL 16 times higher for women with mutations versus without

Mismatch Repair Germline Pathogenic Variants Could Predispose to Uveal Melanoma

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Twenty-one pathogenic variants found in clinically relevant genes, with an enrichment in mismatch repair genes

Childhood Cancer Treatment, Genetics Contribute to Subsequent Neoplasm Risk

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Contributions quantified for subsequent neoplasms in childhood cancer survivors

Shorter Leukocyte Telomere Length Linked to Higher Incidence of Age-Related Brain Diseases

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Shorter leukocyte telomere length linked to higher incidence rates of stroke, dementia, late-life depression as composite and individually

Mitochondrial Genetics Key to Metastatic Melanoma Immunotherapy Resistance

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Patients belonging to haplogroup T exhibit unique nivolumab-resistant baseline peripheral CD8+ T-cell repertoire

Parents Delaying Introduction of Nuts and Eggs, Tied to Increase in Food Allergy Risk

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Most highly allergenic foods introduced to infants at 6 to 9 months

Early Dog Exposure May Modify Genetic Effect on Atopic Eczema Risk

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Findings support observational epidemiology showing protective effect of dog exposure early in life

Central Adiposity Measures Associated With Psoriasis Risk

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Significant interaction seen for full psoriasis polygenic risk score with waist-to-hip ratio on psoriasis risk