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Bisphosphonates reduce the risk of vertebral

Findings Support Bisphosphonate Use in Men With Osteoporosis

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Reduced risk seen for vertebral and possibly nonvertebral fractures
For patients with inflammatory joint diseases

ACR: High Demand for CVD-Preventive Meds in IJD

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High indication for medications, but initiation is infrequent in inflammatory joint disease cohort
Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are associated with increased risk of gastrointestinal adverse events

GI Adverse Events Up With GLP-1 Receptor Agonists

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Risk varies based on dose, background medications, and type of GLP-1 RA
In patients with acute cough

Only Slightly Worse Disease Course for Bacterial LRI

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More often return for second consult than those without bacterial etiology in acute cough
Ticagrelor is not superior to clopidogrel for reduction of cardiovascular events in patients with peripheral artery disease

AHA: Ticagrelor Not Shown to Be Superior to Clopidogrel in PAD

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No better for primary efficacy composite end point of cardiovascular death, myocardial infarction, stroke
The rate of diagnoses for attention-deficit/hyperactivity disorder among U.S. preschoolers has leveled off

Rate of ADHD Diagnoses Stabilizing Among Preschoolers

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2011 AAP treatment guidelines may have contributed to the stabilization
A new injectable medication called inclisiran cuts low-density lipoprotein cholesterol by half or more

AHA: Inclisiran Twice Yearly May Effectively Control Cholesterol

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Injectable medication is a next-level PCSK9 inhibitor
Combining statins with the PCSK9 inhibitor evolocumab can help reduce low-density lipoprotein cholesterol to previously unseen levels

AHA: Evolocumab Can Help Substantially Reduce LDL

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Patients taking evolocumab and statins showed a reduction in arterial plaque volume
For patients with rheumatoid arthritis with interstitial lung disease

ACR: First-Line Rituximab May Improve Survival in RA-ILD

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For RA patients with interstitial lung disease, rituximab linked to improved survival versus TNFi
A combination of a left ventricular assist device and intensive drug therapy may help boost heart function in end-stage heart failure patients

AHA: LVAD Plus Intensive Drug Tx May Aid Heart Failure Patients

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Small study suggests protocol could help avoid need for heart transplantation