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The drug Rubraca (rucaparib) has been granted accelerated approval by the U.S. Food and Drug Administration to treat advanced ovarian cancer.

FDA Grants Fast-Track Approval to Ovarian Cancer Drug

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Rubraca's use is specific to women with deleterious BRCA mutations
For adults with metabolic syndrome

Pioglitazone Improves Whole-Body Aerobic Capacity in MetS

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Improvements in intramyocellular lipid content, skeletal muscle high-energy phosphate metabolism
For superficial or nodular basal cell carcinoma at low-risk sites

Imiquimod Has Sustained Benefit for Basal Cell Carcinoma

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Lower treatment success for imiquimod 5 percent than surgery, but rates similar at three, five years
Hospital admissions related to overdoses from heroin and other opioids rose 64 percent in the United States between 2005 and 2014

Opioid-Related Hospitalizations Up Sharply in the United States

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Admissions due to heroin, prescription opioids rose 64 percent over decade
Synthetic cannabis that triggered a "zombie" outbreak in a New York City neighborhood last summer was significantly more potent than real cannabis

‘Zombie’ Outbreak in NYC Caused by Synthetic Cannabinoid

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AK-47 24 Karat Gold up to 85 times more potent than plant-based cannabis
The Society for Industrial and Organizational Psychology Ototoxicity Scale seems to be best for classifying ototoxicity in cisplatin-treated pediatric patients

SIOP Scale Best for Detecting Ototoxicity With Cisplatin Tx

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Findings show superiority for SIOP in pediatric patients with planned cisplatin-containing treatment
Outcomes-based pricing for novel and expensive biopharmaceuticals is supported in an Ideas and Opinions piece published online Dec. 13 in the Annals of Internal Medicine.

Outcomes-Based Pricing Suggested for New, Costly Drugs

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Strategy would compel manufacturers and insurers to share accountability for clinical outcomes
A data-driven algorithm for personalized diabetes care can yield substantial improvements in hemoglobin A1c

Data-Driven Algorithm Yields Notable Improvements in HbA1c

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Posttreatment HbA1c lower under algorithm-recommended tx versus standard of care
Definitive chemoradiation can potentially cure HIV-associated squamous cell carcinoma of the anal canal

Cetuximab + Chemoradiation Can Cure HIV-Associated Anal Cancer

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Addition of cetuximab may result in less locoregional failure for squamous cell carcinoma of anal canal
A standardized sliding scale insulin (SSI) order sheet can reduce the incidence of SSI-related medication errors

Sliding Scale Insulin Order Sheet Cuts Medication Errors

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Standardized SSI can cut incidence of SSI-related drug errors; doesn't reduce hyper-, hypoglycemia