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Open-label placebos are associated with a positive effect compared with no treatment in a variety of clinical conditions

Positive Clinical Effects Seen for Placebos Without Deception

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Findings based on five studies involving patients with IBS, depression, allergic rhinitis, back pain, ADHD
From 2004 to 2015 there were decreases in the prevalence of advanced disease at initiation of antiretroviral therapy in 10 high-burden countries

Prevalence of Advanced HIV at ART Initiation Decreasing

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Decreases seen in Haiti, Mozambique, Namibia, Nigeria, Swaziland, Uganda, Vietnam, Zimbabwe
Depression treatment with venlafaxine is associated with increased levels of the bone resorption marker C-terminal cross-linking telopeptide of type 1 collagen

Venlafaxine Use Linked to Bone Turnover Markers in Older Adults

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Increase in CTX and decrease in P1NP, consistent with accelerated bone loss with antidepressant tx
There is little agreement between the American Society of Clinical Oncology Value Framework and European Society for Medical Oncology Magnitude of Clinical Benefit Scale

ASCO: Agreement Lacking With ESMO on Most Effective Drugs

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Negative correlation identified for ASCO benefit score with monthly incremental drug costs
Nearly one in six Americans taking non-vitamin K antagonist oral anticoagulants for atrial fibrillation may not be receiving the proper dose

Many Taking NOACs for A-Fib May Not Be Getting Right Dose

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Study of newer medications finds 16 percent receive too much or too little
Two new medications that target specific genetic mutations may improve survival for patients with specific types of advanced non-small-cell lung cancer

ASCO: Novel Meds Show Promise in Advanced NSCLC

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Results presented from two phase III trials
For patients with allergic rhinitis

Grass Pollen SLIT Slows Course of Allergic Rhinitis, Asthma

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Tx associated with slower AR progression, less frequent asthma onset, slower asthma progression
Olaparib (Lynparza) monotherapy can provide a significant benefit over standard therapy in women with human epidermal growth factor receptor type 2-negative metastatic breast cancer and a germline BRCA mutation

ASCO: Olaparib Efficacious in BRCA-Related Breast Cancer

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May offer a new treatment for women with advanced BRCA-related disease, researchers say
A patient-reported outcome intervention for symptom monitoring is associated with improved overall survival for patients treated with chemotherapy for metastatic solid tumors

ASCO: Survival Up With Patient-Reported Outcomes During CA Tx

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Improved survival with patient-reported outcomes for symptom monitoring in metastatic cancer
An experimental drug that targets tropomyosin receptor kinase fusion

ASCO: Gene-Targeted Drug Shows Efficacy for Child, Adult Cancers

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Larotrectinib targets tropomyosin receptor kinase fusion proteins