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Depression treatment with venlafaxine is associated with increased levels of the bone resorption marker C-terminal cross-linking telopeptide of type 1 collagen

Venlafaxine Use Linked to Bone Turnover Markers in Older Adults

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Increase in CTX and decrease in P1NP, consistent with accelerated bone loss with antidepressant tx
There is little agreement between the American Society of Clinical Oncology Value Framework and European Society for Medical Oncology Magnitude of Clinical Benefit Scale

ASCO: Agreement Lacking With ESMO on Most Effective Drugs

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Negative correlation identified for ASCO benefit score with monthly incremental drug costs
Nearly one in six Americans taking non-vitamin K antagonist oral anticoagulants for atrial fibrillation may not be receiving the proper dose

Many Taking NOACs for A-Fib May Not Be Getting Right Dose

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Study of newer medications finds 16 percent receive too much or too little
Two new medications that target specific genetic mutations may improve survival for patients with specific types of advanced non-small-cell lung cancer

ASCO: Novel Meds Show Promise in Advanced NSCLC

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Results presented from two phase III trials
For patients with allergic rhinitis

Grass Pollen SLIT Slows Course of Allergic Rhinitis, Asthma

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Tx associated with slower AR progression, less frequent asthma onset, slower asthma progression
Olaparib (Lynparza) monotherapy can provide a significant benefit over standard therapy in women with human epidermal growth factor receptor type 2-negative metastatic breast cancer and a germline BRCA mutation

ASCO: Olaparib Efficacious in BRCA-Related Breast Cancer

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May offer a new treatment for women with advanced BRCA-related disease, researchers say
A patient-reported outcome intervention for symptom monitoring is associated with improved overall survival for patients treated with chemotherapy for metastatic solid tumors

ASCO: Survival Up With Patient-Reported Outcomes During CA Tx

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Improved survival with patient-reported outcomes for symptom monitoring in metastatic cancer
An experimental drug that targets tropomyosin receptor kinase fusion

ASCO: Gene-Targeted Drug Shows Efficacy for Child, Adult Cancers

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Larotrectinib targets tropomyosin receptor kinase fusion proteins
In men with advanced prostate cancer

ASCO: Abiraterone Extends Survival in Metastatic Prostate CA

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Side effects noted with use of abiraterone similar to those already found in patients taking the drug
For patients taking oral anticoagulants

Model Predicts Acute GI Bleeding in Anticoagulated Patients

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New scoring model includes five factors predictive of GI bleeding in patients taking oral anticoagulants