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Patients with a CYP2C19 loss-of-function allele have increased risk of major adverse cardiovascular events with clopidogrel versus alternative antiplatelet therapy after percutaneous coronary intervention

CYP2C19-Genotype Guided Antiplatelet Tx May Be Beneficial

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MACE risk up with clopidogrel versus alternative therapy for patients with CYP2C19 loss-of-function allele
From 2005 to 2015 there was a decrease in the proportion of infants aged ≤60 days with a urinary tract infection who received four or more days of intravenous antibiotics

Drop in Proportion of Neonates With Long IV Therapy for UTI

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Decrease from 50 percent in 2005 to 19 percent in 2015; not linked to increase in hospital readmissions
PARP inhibitors demonstrate activity in triple-negative breast cancer tumors without BRCA1/2 mutations

PARP Inhibitors Promising Beyond BRCA1/2 Altered Tumors

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Talazoparib caused regression in 5 patient-derived xenografts, 4 without germline BRCA1/2 mutations

American College of Allergy, Asthma and Immunology, Oct. 26-30

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The 2017 Annual Meeting of the American College of Allergy, Asthma & Immunology The annual meeting of the American College of...
The ability to purchase a product containing a class 3 topical steroid online

Prescription-Strength Steroids Sold Without Prescription

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Case report highlights Funbact-A, available online, which contains prescription-strength betamethasone
Not all prescription drug users report receiving warnings about driving impairment

Driving Impairment Warnings Often Not Given With Rx Meds

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For most drug categories, those who do receive warnings perceive higher risk of impaired driving
For adolescents with type 1 diabetes and high levels of albumin excretion

ACE Inhibitor, Statin No Benefit for T1DM, High Albumin Excretion

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Use of ACE inhibitor and a statin does not change albumin-to-creatinine ratio in adolescents with T1DM
Gene replacement therapy is beneficial in spinal muscular atrophy type 1

Gene Replacement Tx Beneficial in Spinal Muscular Atrophy

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And nusinersen improves motor-milestone response for infants with spinal muscular atrophy

October 2017 Briefing – Pharmacy

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for October 2017. This roundup includes the latest...
Lenalidomide produces hematologic responses in myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis

Response to Lenalidomide Often Suboptimal in MDS/MPN-RS-T

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Hematological responses seen in three patients with MDS/MPN-RS-T, but the responses not durable