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Sertraline treatment does not significantly improve depressive symptoms among patients with non-dialysis-dependent chronic kidney disease and major depressive disorder

Sertraline Treatment No Benefit for Depressive Symptoms in CKD

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No improvement for patients with MDD and chronic kidney disease without dialysis dependence
Most people complete treatment for latent tuberculosis without direct observation

Completion Likely With Self-Administration of TB Treatment

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Self-administration without reminders is noninferior to direct observation in patients with latent TB
Influenza vaccination in the pediatric emergency department setting appears to be a cost-effective strategy

Influenza Vaccines in Pediatric ERs Likely Cost-Effective

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Vaccinating all patients saves $33.51 per flu case averted, averages 27 fewer cases per 1,000 patients
A novel method has been developed to enhance the prevalence estimates of diabetes and prediabetes

Novel Method Developed for Estimating Prevalence of Diabetes

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Authors reweighted surveys, other data sources with population undercoverage to enhance estimates
Proton pump inhibitor users have an increased risk of chronic kidney disease or end-stage renal disease

ASN: PPIs Associated With Increased Risk of Kidney Disease

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Risk for both chronic kidney disease, end-stage renal disease higher with proton pump inhibitor use
For patients with later-stage autosomal dominant polycystic kidney disease

ASN: Tolvaptan Slows eGFR Decline in Later-Stage ADPKD

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Reduction in decline in eGFR for patients with later-stage autosomal dominant polycystic kidney disease
For patients with rheumatoid arthritis

ACR: Temporary Cessation of MTX Ups Flu Shot Immunogenicity

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Findings in patients with rheumatoid arthritis taking a stable dose of methotrexate
For patients with rheumatoid arthritis

ACR: Opioids, SSRIs Tied to Higher Fracture Risk in RA

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Increased risk of osteoporotic fracture with selective serotonin reuptake inhibitors, opioids of any strength
Tezacaftor-ivacaftor or ivacaftor alone is effective for patients with cystic fibrosis who are heterozygous for the Phe508del deletion

Tezacaftor-Ivacaftor, Ivacaftor Alone Effective in CF

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And tezacaftor-ivacaftor effective for cystic fibrosis patients homozygous for CFTR Phe508del mutation
For patients with rheumatoid arthritis

ACR: Successful Tapering of DMARDs in RA Explored

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Low level of serum CRP at baseline linked to successful down-titration in multivariate analysis