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For patients with dementia with Lewy bodies

Adjunct Zonisamide Beneficial in Dementia With Lewy Bodies

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Zonisamide as an adjunct to levodopa improves parkinsonism without worsening cognitive function
Clinical practice guidelines for anticoagulation therapy for cardiopulmonary bypass have been developed and were published in the February issue of the Annals of Thoracic Surgery.

Anticoagulation Guidance Issued for Cardiopulmonary Bypass

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Recommendations for heparin dosing and monitoring, contraindications and alternatives, reversal
Urinary tract infections (UTIs) are common in nursing home residents

Confusion Common in Seniors Prescribed Antibiotics for UTI

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Confusion independently associated with receipt of antibiotics for UTI in nursing home residents
Prior authorization requirements are greater for proprotein convertase subtilisin/kexin type 9 inhibitors than for other cardiometabolic drugs

Greater Prior Authorization Requirements Seen for PCSK9i Rx

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PA requirements are more extensive for PCSK9is than for other cardiometabolic drugs
For patients with autosomal recessive hypercholesterolemia

LDL-C Still High in Autosomal Recessive Hypercholesterolemia

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Increase in use of high-intensity statin, ezetimibe; only 23.1 percent reach LDL-C of <100mg/dL
Patient reminder and recall systems seem to be effective for improving receipt of immunizations

Reminder, Recall Systems Improve Immunization Uptake

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Based on high certainty evidence, postcards, text messages, auto-dialer improve receipt of vaccines
Having a pharmacist at bedside during acute ischemic stroke is associated with significantly shorter door-to-needle times

Pharmacist Participation in Stroke Response Cuts Door➜Needle Time

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Pharmacist helps reduces DTN time by median 23.5 min; ups percent of patients meeting ≤60 min goal
Bariatric surgery is associated with lower risks of obesity-related comorbidities but a clinically important increased risk for complications compared with medical treatment

Increased Risk of Complications With Bariatric Surgery

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Lower risks of obesity-related comorbidities but increased risk for complications versus medical tx
Doxylamine-pyridoxine may be beneficial for nausea and vomiting symptoms in early pregnancy

Value of Doxylamine-Pyridoxine Questioned in Early Pregnancy

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Greater improvement in symptom scores versus placebo, but clinical relevance unclear
Onabotulinum toxin-A injections can improve sleep bruxism

Onabotulinum Toxin-A Can Safely Improve Sleep Bruxism

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Improved clinical global impression and change in visual analog scale, pain at 4 to 8 weeks post therapy